The changes of antithrombotic function of blood and blood vessel wall with age

为了阐明血管和血管壁抗血栓功能的年龄依赖性，我们测定了正常人和有血管病史的新生儿的血小板聚集、天然凝血抑制物、纤溶因子以及一些止血和血栓形成的分子标志物。结果如下：1)新生儿血浆中血小板、凝血和纤溶相关蛋白的分子标志物水平升高，表明新生儿的血小板、凝血和纤溶系统处于激活状态。2)新生儿血浆天然凝血抑制物水平低于成人。然而，在1岁以上的受试者中，未观察到天然凝血抑制物的年龄依赖性。3)急性血管炎患者可见血小板和凝血系统的激活。川崎病患者发病后1年以上即可观察到上述系统的激活。另一方面，这些患者的纤溶系统受到抑制。

In order to clarify the age dependence of antithrombotic function of blood and blood vessel wall, we measured platelet aggregation, natural coagulation inhibitors, fibrinolytic factors and some molecular markers of hemostasis and thrombosis in normal subjects and subjects with present or past history of vasculitis.Results obtained from this research were as follow.1) The plasma levels of molecular markers of platelet, coagulation and fibrinolysis-related proteins were increased in newborn infants, indicating that platelet, coagulation and fibrinolysis systems were activated in neonates. However, no change of these parameters with age was not seen in subjects beyond 1 years old of age.2) The plasma levels of natural coagulation inhibitors were lower in newborn infants than those in adults. However, no age dependence of natural coagulation inhibitors was observed in subjects beyond 1 years old of age.3) The activation of platelet and coagulation system was seen in patients with acute vasculitis. In the patients with kawasaki disease, the activation of those system was observed beyond 1 year after the onset of the disease. On the other hand, fibrinolytic system was depressed in those patients.