THE EFFECTS OF STELLATE GANGLION BLOCK TOGETHER WITH OXYGEN.CARBON DIOXIDE OR PROSTAGLANDIN E1 ON CRANIAL CIRCULATION

我研究了左星状神经节阻滞（LtSGB）联合5%二氧化碳吸入或静脉注射前列腺素E1 （PGE1）对狗脑血流量（CBF）的影响。采用激光多普勒血流仪圆盘式探头在大脑皮层表面测量脑血流。LtSGB没有改变血压、心率和心输出量。LtSGB显著增加左颈总血流量（Ca-BF）和左椎血流量（VBF），降低SGB侧CBF。吸入5% CO2诱导高碳酸血症（PaCO2:50mmHg）和CBF增加。这些结果表明，SGB增加了SGB侧颈外动脉血流量，而不是颈内动脉血流量，因此CO2吸入对CBF的干扰是有效的，而不是SGB。200ng/kg/min剂量的PGE1通过其直接血管扩张作用使Ca-BF和VBF增加约10%，但未改变CBF。SGB后，PGE1的作用随SGB侧Ca-BF和VBF的增加速率明显增强。上述结果提示PGE1对颈外动脉、椎动脉及SGB均有血管扩张作用，且与交感神经节阻滞相关的协同作用显著。因此，SGB联合PGE1治疗颈外动脉和椎动脉供血不足更有效。

I studied the effects of left stellate ganglion block (LtSGB) used together with 5% CO2 inhalation or intravenous prostaglandin E1 (PGE1) for cerebral blood flow (CBF) in dogs. CBF was measured at the surface of cerebral cortex using disc-type-probe of laser doppler flow meter. LtSGB didn't change blood pressure, heart rate and cardiac output.LtSGB significantly increased left common carotid blood flow (Ca-BF) and left vertebral blood flow (VBF), but decreased CBF in SGB side. Inhalation of 5% CO2 induced hypercapnia (PaCO2:50mmHg) and increased CBF. These findings suggest that SGB increase external carotid blood flow in SGB side, but not internal carotid blood flow, therefore CO2 inhalation is effective for disturbance of CBF rather than SGB.The dose of 200ng/kg/min of PGE1 increased Ca-BF and VBF as much as approximately 10% by its direct vasodilative action, but didn't change CBF. After SGB, the effect of PGE1 was augumented clearly at the rate of increase of Ca-BF and VBF in SGB side.These findings suggest PGE1 has vasodilative effects for external carotid artery and vertebral artery as well as SGB,and remarkable synergic effects related to the sympathetic ganglion block. So, SGB using together with PGE1 is more effective for blood insufficiency of the region of external carotid artery and vertebral artery.