Application and further development of fixation-controlled tests of macular function in AMD

目前还缺乏标准化的注视控制黄斑功能测试技术。由于我们部门长期以来对使用扫描激光检眼镜（SLO）评估阅读性能和注视行为的研究工作，已经开发出可用于参与治疗试验的年龄相关黄斑变性（ARMD）患者治疗结局标准化评价的方法。因此，本项目的目标是为核心中心柏林、科隆和图宾根提供此类技术，用于评估SLO固定，以开发精细的任务调整方法，用于精确监测治疗干预的效果。为了对注视点和稳定性进行分类，还将针对非中心注视的情况修改半自动评估程序，并计算注视质量指数（FQI）。将确定FQI的正常值及其随年龄的变化。新技术的发展包括针对非中心注视情况优化的标准化SLO视野检查程序，以取代将在研究开始时使用的非标准化Rodenstock暗点测量。此外，将开发一种利用He-Ne激光投射刺激图案的固定控制多焦ERG（MF-ERG）装置。

There is a lack of standardized techniques for fixationcontrolled macular function tests. Due to the long-standing research efforts of our department on the assessment of reading performance and fixation behaviour with the Scanning-LaserOphthalmoscope (SLO), methods have been developed that can be used for the standardized evaluation of the outcome of treatment in patients with Age related macula degeneration (ARMD) participating in the therapeutical trial. The goal of this project is thus to provide such techniques for the assessment of fixation with an SLO to the core centers Berlin, Cologne, and Tuebingen to develop refined task-adjusted methods for precise monitoring the effect of therapeutic intervention. To classify fixation locus and stability, a semi-automated evaluation program will be modified also for the case of non-central fixation, and an index of fixation quality (FQI) will be calculated. Normal values of the FQI and their variation by age will be determined. Developments of new techniques include a standardized SLO-perimetry program optimized for the case of non-central fixation to replace the non-standardized Rodenstock scotometry which will be used at the beginning of the study. In addition, a setup for fixationcontrolled multifocal ERG (MF-ERG) will be development that utilizes the He-Ne-laser for projection of the stimulus pattern.