Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA

单核金属配合物与DNA相互作用的研究大大增加了我们对小分子识别DNA上特定位点的方式的理解。然而，为了设计针对特定基因的药物，从而有可能控制基因表达，有必要研究可以与较大DNA片段相关的金属配合物的结合。利用申请人的综合专业知识，建议立体特异性合成双核复合物并研究它们的DNA结合。这将极大地帮助开发能够选择性靶向基因和改变DNA的药物。

Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. Using the combined expertise of the applicants, it is proposed to stereospecifically synthesise dinuclear complexes and study their DNA binding. This will greatly assist in the development of drugs that can selectively target genes and altered DNA.