Studies on intervention to atherosclerosis with special reference to cell membrane impairment

1)比较健康体检应答者和非应答者的生活方式和卒中发生率，以评价循环系统疾病健康体检的有效性和效率。与应答者相比，无应答者表现出相对较差的生活方式，但高血压患病率没有显著差异。2)血清硫氰酸盐(SCN)是卒中的危险因素。研究对象为在卒中患者登记系统登记的52例卒中患者，男22例，女30例。调整了性别、年龄和血压的对照组是从1987~1988年年度体检的参与者中挑选出来的。3)尿酸和抗坏血酸对臭氧暴露所致红细胞膜Na-KATPase活性降低有预防作用。4)尿致突变活性与血清硫氰酸盐水平呈正相关(p&lt；0.01)，与尿肌酸水平无相关性。此外，血清硫氰酸盐水平和尿致突变活性随戒烟时间的延长而降低。血清硫氰酸盐水平反映了尿液的致突变活性，可作为慢性吸烟暴露毒性的指标。

1) In order to estimate the effectiveness and and efficiency of the health examination for circulatory diseases, life style and stroke incidence were compared between the responders and non-responders to a health examination. The non-responders show a relatively undesirable life style in comparison with the responders, but no significant differences in hypertension rate is observed.2) The serum thiocyanate (SCN) was investigated as a risk factor of stroke. The subjects were 52 stroke patients (22 males and 30 females) who were registrated in registry system for stroke patients. The controls who were adjusted sex, age and blood pressure with cases were selected from participants in their annual medical check-ups in 1987 to 1988. The SCN level of cases was significantly higher than that of controls(p<0.05).3) Uric acid and ascorbic acid showed the preventive effects on erythrocyte membrane Na-KATPase activies reduced by ozone exposure in vitro.4) Urinary mutagenic activities correlated positively with serum thiocyanate levels (p<0.01), but did not with urinary continine levels. Moreover, serum thiocyanate level and urinary mutagenic activity decreased with the time of cigarette cessation. Serum thiocyanate levels reflected urinary mutagenic activities and it could be used for an indicator of toxicity of chronic exposure of cigarette smoking.