THE CROSS TALK OF SIGNAL TRANSMISSION BETWEEN THE RECEPTOR AND THE CHANNEL

本文研究了代谢型谷氨酸、5-羟色胺_2、TRH和M受体反应的第二信使系统及其相互关系。这表明神经元在第二信使水平(Akaike)选择和整合来自不同路径的输入。神经元的兴奋性强烈依赖于葡萄糖代谢(Akasu)。无氧无糖条件下的去极化是由于钙离子依赖的阳离子通透性增加引起的。在低氧条件下，Ca~(2+)-Gt~(2+)/CaM-KⅡ和C-K(Higashi)激活引起细胞超极化。环状ADP核糖的合成参与了Ca~(2+)诱导的Ca~(2+)释放，并发现了线粒体环化ADP-核糖的新机制(Kuba)。细胞内Na~(2+)调节细胞内钙离子浓度(Sorimachi)。Ca^lt；2+与CaM结合，激活肌球蛋白轻链激酶。这似乎与突触前神经递质的释放有关(小林)。在高温下，体温调节中枢的温敏神经元诱发的钠电流通过“昏睡”样通道。PC-12细胞似乎是研究中枢冷敏感神经元(Kiyohara)的有用模型。神经系统的初始发育过程(Takahashi)、电压依赖性细胞内钙离子释放机制(Inoue)、消化吸收离子通道的作用(Okada、Kitazato)、第二信使(Takenaka)调节轴突流量的作用(Takenaka)、胃平滑肌的自主收缩(Tomita)、依赖内皮细胞的血管平滑肌超极化(Suzuki)、鱿鱼的氯离子(Yamagishi)、钠离子通道(Seyama，Noma)和缝隙连接(Tonosaki)。

The second messenger system of the metabotropic glutamate, serotonin_2, TRH and muscarinic_3 receptors-induced responses and relationship among them was investigated. It was suggested that neurons selects and integrates the inputs from different path ways at the 2nd messenger level (Akaike). The excitability of neurons were strongly depended upon the glucose metabolism (Akasu). Depolarization at no-oxygen and no-glucose condition was caused by the increase of Ca^<2+>-dependent cation permeability. Hyperpolarization at the low oxygen condition was cased by activation of Ca^<2+>/CaM kinase II and C kinase (Higashi). Synthesis of cyclic ADP-ribose was involved in the Ca^<2+>-induced Ca^<2+> release and new mechanism of that from mitochondria were also found (Kuba). Intracellular Na^+ regulate the intracellular Ca^<2+> concentration (Sorimachi). Ca^<2+> binds to CaM which activates the myosin light chain kinase. This seems to be involved in the presynaptic release of neurotransmitterrs (Kobayashi). The warm-sensitive neurons of thermoregulation center induced Na^+ current passed through "sleepy" like channel at the high temperature. PC-12 cells seems to be useful model for the study of central cool-sensitive neurons (Kiyohara). It was also studied that the process of initial development of nervous system (Takahashi), voltage-dependent intracellular Ca^<2+> release mechanism (Inoue), the role of ion channel for digestion and absorption (Okada, Kitazato), modulation of axonal flow by second messenger (Takenaka), the automatic contraction of stomach smooth muscle (Tomita), endothelial cell dependent hyperpolarization of vascular smooth muscle (Suzuki), Cl^- of squid (Yamagishi), Na^+ channel (Seyama, Noma) and gap junction (Tonosaki).