A new biomechanical model for understanding aging of stored Red Blood Cells

该项目计划开发一种新的建模框架，以准确地表示红细胞（RBC）在储存条件下随时间推移的生物力学特性。储存的RBC遭受与衰老相关的变形性变化，这阻碍了RBC功能。该框架旨在整合RBC膜，内部血红蛋白和外部存储溶液的模型，并通过嵌入时间相关性来解释老化效应。它应该提供新的见解和理解的机制，变形性变化的红细胞储存寿命。因此，它应该显着改善血液储存行业的做法，改善红细胞储存协议与预防性老化策略。

This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent correlations. It should provide new insights and understanding of the mechanisms of deformability changes of RBCs during stored lifespan. Therefore, it should significantly improve blood storage industry practices in terms of improving RBC storage protocols with preventative ageing strategies.