Biomechanics, Biomaterials and Multimodal Tissue Imaging Core (BBMTI Core)

生物力学、生物材料和多模态组织成像核心（BBMTI 核心）

• 批准号: 10232836
• 负责人: Hani A Awad
• 金额: $ 23.39万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10232836
• 关键词: 3D Print; Achievement; Address; Algorithms; Animal Model; Award; Biocompatible Materials; Biology; Bioluminescence; Biomechanics; Cadaver; Cells; Clinical Management; Collaborations; Development; Diffuse; Disease; Equipment; Faculty; Fluorescence; Fostering; Funding; Goals; Grant; Growth Factor; Health; Human; Hydrogels; Implant; In Vitro; Individual; Infrastructure; Interdisciplinary Study; International; Joints; Laboratories; Learning; Measurable; Medical Imaging; Modeling; Muscle; Musculoskeletal; Musculoskeletal Diseases; Operative Surgical Procedures; Orthopedics; Pathology; Peer Review; Peptide Synthesis; Periodicity; Pharmaceutical Preparations; Polymers; Procedures; Productivity; Publications; Publishing; Quality Control; Raman Spectrum Analysis; Reproducibility; Research; Research Personnel; Resources; Secure; Services; System; Technology; Testing; Tissue Microarray; Tissue imaging; Tissues; Training; Trauma; Ultrasonography; United States National Institutes of Health; Universities; base; bench to bedside; biomechanical test; bone; bone fracture repair; bone quality; catalyst; clinically relevant; cohesion; cost effective; cost effectiveness; experience; healing; image processing; imaging modality; in vivo Model; in vivo imaging; innovation; innovative technologies; lectures; medical specialties; microCT; microphysiology system; minimally invasive; multimodality; musculoskeletal injury; nanoparticle; new technology; novel; pre-clinical; preclinical imaging; programs; ranpirnase; repaired; skeletal; success; tomography; tool

The Biomechanics, Biomaterials, and Multimodal Tissue Imaging (B2MTI) Core is an indispensable catalyst for efficiency and innovation in the University of Rochester Resource-based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR). Over the past 9 years, the B2MTI Core utilized state-of-the-art equipment to provide scientific services, including biomechanical testing, biomaterials synthesis, fabrication and characterization, as well as preclinical and medical imaging in models of musculoskeletal pathologies and repair. In this renewal application, we will continue to provide ROCSTARR investigators with the scientific expertise and services that meet the standards of efficiency, scientific rigor, and reproducibility. In addition, we will foster the development of innovative technologies by the ROCSTARR Investigators to catalyze funding and cultivate collaborative research programs that address the challenges that impact musculoskeletal health. Our Aims include: 1) providing services and facilitating innovations in biomechanical testing at multiple scales in models of orthopaedic trauma and disease, as well as supporting clinically relevant cadaveric studies of surgical implants and repair procedures; 2) supporting innovations in biomaterials for drug and cell delivery and expanding the scope of biomaterials integration into novel microphysiological models of musculoskeletal tissues and systems (e.g., tissue chips); 3) supporting multimodal preclinical imaging including micro-CT, multispectral (fluorescence and bioluminescence), near infrared, and ultrasound imaging, and exploring innovations in other imaging modalities including Raman Spectroscopy and Diffuse Correlation Tomography for applications in the assessment of bone quality and fracture repair; 4) integrating expert ROCSTARR faculty as Advisors in specialty Sub-Cores to offer conceptual and technical guidance and expanded access to novel technologies; and 5) interacting with the Core Users Committee to maintain cost-effective access to Core resources and supporting the Admin Core’s Enrichment initiatives including the P30 Pilots and the new Discovery Fund. Over the past 9 years, the B2MTI Core has proven the added value of integrating its services to overcome the inefficiencies of uncoordinated efforts from multiple ROCSTARR laboratories, and has had a measurable impact on the research programs of NIH-funded and New/Early Stage ROCSTARR Investigators. The B2MTI Core will continue to foster collaborative funding and high impact scientific publications that advance musculoskeletal discoveries and innovations from the bench to the bedside.

生物力学、生物材料和多模态组织成像（B2 MTI）核心是不可或缺的催化剂， 罗切斯特大学骨、肌肉和骨骼资源中心的效率和创新 骨科研究（ROCSTARR）。在过去的9年里，B2 MTI核心采用了最先进的 提供科学服务的设备，包括生物力学测试、生物材料合成、制造 和表征，以及肌肉骨骼病理模型的临床前和医学成像， 修复.在这次更新申请中，我们将继续为ROCSTARR研究人员提供科学的 专业知识和服务，满足效率，科学严谨性和可重复性的标准。另外我们 将促进ROCSTARR研究人员开发创新技术，以促进资金和 培养合作研究计划，解决影响肌肉骨骼健康的挑战。我们 目的包括：1）在多个尺度上提供生物力学测试服务并促进创新， 骨科创伤和疾病的模型，以及支持临床相关的尸体研究， 外科植入物和修复程序; 2）支持用于药物和细胞递送的生物材料的创新， 将生物材料整合的范围扩展到肌肉骨骼的新型微生理学模型中 组织和系统（例如，组织芯片）; 3）支持包括微CT的多模式临床前成像， 多光谱（荧光和生物发光）、近红外和超声成像，以及探索 其他成像模式的创新，包括拉曼光谱和扩散相关断层扫描 应用于骨质量和骨折修复的评估; 4）整合ROCSTARR专家团队 作为专业子核心的顾问，提供概念和技术指导，并扩大对新技术的访问 5）与核心用户委员会互动，以保持对核心技术的成本效益访问 资源和支持管理核心的丰富举措，包括P30试点和新的 发现基金。在过去的9年里，B2 MTI核心已经证明了整合其服务的附加值 为了克服多个实验室不协调的工作效率低下， 对NIH资助的和新的/早期的ROCSTARR研究者的研究计划产生可衡量的影响。 B2 MTI核心将继续促进合作资助和高影响力的科学出版物， 将肌肉骨骼的发现和创新从实验室推向临床。