Studies on Safety and Effectiveness of Dentin Pretreatment Agents, Pulp Capping Agents and Base Materials

1.通过测定O_2^-的产生和LDH的释放，建立了一种新的牙科材料对人中性粒细胞的细胞毒性试验，胶原结合BMP诱导骨髓基质细胞向成骨细胞分化。（shimokobe，Matsui和Inoue）2.抗菌覆盖剂（α-TCP与混合抗菌药物）有效地消毒了细菌污染的牙髓组织而不破坏周围的牙髓组织（Iwaku）。3.乙二醇或1，6-己二醇的水溶液的牙本质预充被认为是理想的，因为防止了光活化树脂复合物的收缩间隙的形成。二醇溶液的使用避免了甲基丙烯酸酯衍生物对皮肤组织可能产生的副作用。当牙本质表面用螯合剂（植酸）和金属离子（Sn^<2+>）处理时，树脂与牙本质的剪切粘结强度在1，000次热循环后没有变化（Kohno和Sakamo ...更多信息 5.玻璃离子衬层材料在10种盖髓材料中细胞生长最强，用UMU试剂盒（Aono）检测未显示出任何致突变性6.含La的牙本质表面处理后，牙本质表面硬度、耐酸性和与树脂粘结剂的粘结强度均有所提高（Hara和Senda）7.在用于客观测量基础水泥的不透射线性的Al、Cu或Ti的三种实验比色计中，钛-钴计显示出最好的结果（Fujii和Narikawa）。8.增加单宁酸浓度和增加在酸中的孵育时间有效地降低了牙本质胶原的溶解量10.磷酸四钙（TTCP）的研磨提高了基于聚甲基乙烯基醚-马来酸和TTCP的骨水泥的机械强度，降低了其溶解度，并加速了羟基磷灰石的形成（Matsuya）。少

1.A new cytotoxic test of dental materials on human neutrophils was established by determining the production of O_2^- and the release of LDH.The addition of collagen-combined BMP induces differentiation of bone marrow stromal cells into osteoblasts.(shimokobe, Matsui and Inoue)2.The antibacterial capping agent(alpha-TCP with mixed antibacterial drugs)effectively disinfected bacterially contaminated pulp tissue without destroying surrounding pulp tissue(Iwaku).3.The dentin priming by the aqueous solution of the ethylene glycol or 1,6-hexanediol was considered to be desirable because the contraction gap formation of the light activated resin compostite was prevented. And the possible side effect on the skin tissue by the methacrylate derivatives was avoided by using the diol solutions.(Hisamitsu)4.When the dentin surface was treated with chelating agent(phytic acid)and metallic ion(Sn^<2+>), shear bond strength of resin to dentin did not change after 1,000 thermo-cycled(Kohno and Sakamo … More to).5.Glass ionomer lining materials showed the strongest cellular growth of ten pulp capping materials tested which did not show any mutagenic potential using UMU-test kit(Aono).6.The dentin surface treated with La-containing conditioner showed higher hardness, better acid resistance and higher bond strength with resin bonding agent(Hara and Senda).7.Among three experimental penetrometers of Al, Cu or Ti for objective measuring of radiopacity of base cements, Ti-penetrometer revealed the best results(Fujii and Narikawa).8.Increased concentration of tannic acid and increased incubation times in the acid effectively decreased the dissolved amount of dentin collagen(Shintani).9.Not only calcium hydroxide but also alkyl salicylates influenced the antimicrobial activity of the set calcium hydroxide cements(Nagasawa).10.The grinding of tetracalcium phosphate(TTCP)increased the mcchanical strength of the cement based on polymethyl vinyl ether-maleic acid and TTCP,decreased its solubility, and accelerated the hydroxyapatite formation(Matsuya). Less