The Basic and Clinical Study for Regional Cerebral Blood Flow in Affective Disorders using stable Xe-CT.

采用稳定性氙增强CT（Xe-CT）对情感性精神障碍患者的局部脑血流量（rCBF）进行了研究。研究对象为17例情感性精神障碍患者和10名男性健康志愿者，其中抑郁症（MD）11例，双相情感障碍（BD）6例，符合DSM-III-R诊断标准。平均年龄分别为53.2岁、47.0岁和40.4岁。两组患者和对照组的各脑区rCBF绝对值均无半球间差异。在MD患者中。右侧额叶和双侧中央前皮质区的rCBF与对照组相比显著降低。另一方面，BD患者显示右颞叶皮层的rCBF显著降低。对6例患者（2例MD和4例BD）恢复前后的rCBF进行比较。临床症状改善的患者皮质血流量无明显变化，但皮质下血流量增加，尤其是基底节血流量增加。此外，用SPECT和~ <123>1H Iomazenil研究了情感性障碍和焦虑症患者的中枢苯二氮卓受体结合。患者额、顶、颞、枕区结合电位降低。左额、右颞区结合电位与HAM-A评分呈负相关

With stable xenon-enhanced computed tomography (Xe-CT), regional cerebral blood flow (rCBF) in the patients with affective disorder were investigated. The subjects were 17 in- and outpatients with affective disorders, which consists of 11 patients with major depression (MD) and 6 patients with bipolar disorder (BD) according to the DSM-III-R criteria, and 10 male healthy volunteers. Their mean ages were 53.2 year, 47.0 year and 40.4 year, respectively. Both patients and controls did not present the interhemispheric differences in absolute rCBF values for every regions. In MD patients. rCBF in right frontal and bilateral precentral cortical regions were significantly reduced as compared with controls. On the other hand, BD patients showed a significant reduced rCBF in right temporal cortex. In six patients (2 MD and 4 BD), the rCBF were compared between before and after recovery. The patients with the clinical improvement showed no remarkable change in cortical blood flow, but they showed increased subcortical blood flow, especially in basal ganglia.In addition, central benzodiazepine receptor bindings using SPECT and ^<123>I Iomazenil in the patients with affective disorders and anxiety disorders were investigated. The binding potential was decreased in frontal, parietal, temporal and occipital region in the patients. The binding potential in left frontal and right temporal area was corelated negatively with HAM-A score