Development of a Spatio-temporal Analyzing System for Cardiac Function by using a Portable RI Monitoring Apparatus

该项目的最终目标是在早期阶段发现心脏异常。为此，通过结合来自不同模式的数据来对心功能进行空间-临时评估。一是用新设计的便携式监护系统对心输出量进行长期观察，二是每隔一段时间对HART进行精确的形态观察。RI心脏监测系统连续测量RI信号与左心室RI试剂的体积成比例，并开发了从MRI、血管造影等方面评估心功能的程序。RI监测系统的原型由镉镉探测器、放大器、光谱鉴别器和掌上电脑组成。该系统从患者的RI中检测伽马射线，并连续测量特定的谱峰，以区分感兴趣的信号和背景散射。为了补偿背景信号，还引入了一个参考检测器。通过计算机仿真和体模初步实验验证了该系统的工作原理和基本特性，并提出了基于MRI的三维体积测量算法和基于观测图像序列的三维运动分析算法。还开发了一种集成显示技术，以显示关于同一对象的不同模式的心脏信息。此外，还发展了几种相关的成像和图像处理技术，如SR-CT、ESR-CT等。未来的问题是建立更实用的监测系统，并改进对来自多个通道的信息的综合评估程序。

The final goal of this project is to detect cardiac abnormality in its early stage. For this purpose, cardiac function is spatio-temporarily evaluated by combining data from different modalities. One is the long term observation of cardiac output by newly designed portable monitoring system, and the other is the precise morphological observation of hart taken at intervals. The RI cardiac monitoring system measures continuously RI signals proportional to the volume of RI agents in the left ventricle and the procedures are developed to evaluate cardiac functions from MRI,angiogram and so on.A prototype of the RI monitoring system is composed of a CdTe detector, an amplifier, a spectrum discriminator and a palm size computer. This system detects gamma ray from RI in the patient, and it measeres continuously the specific spectrum peak to discriminate the interesting signal from background scattering. A reference detector is also introduced to compensate background signal. The principle and fundamental characteristics of the system are examined by computer simulation and preliminary experiments with phantom.On the other hand, we have prepared several algorithms for 3D volumetry from MRI and 3D motion analysis from observed image sequence. An integrated display technique is also developed to show cardiac information from different modalities about the same object. Moreover several related imaging and image processing techniques are developed, i.e., SR-CT,ESR-CT and so on.Future problems are to establish more practical monitoring system and to improve integrated evaluation procedures for information from several modalities.