Dynamic neuronal assemblies underling paired associative memory in the rat

记忆信息处理的基本代码是“细胞组装”，即，重叠的神经元群体，在群体内和群体之间具有灵活的功能连接。本系列实验研究了细胞集合体在处理几种不同的记忆过程中的两个主要特性，即神经元的重叠性和突触连接的动力学，实验一比较了对同一刺激的不同记忆过程，即工作记忆和参考记忆。在他们的任务中，设备，刺激和大鼠是相同的，只有所需的过程类型不同。第二个实验比较了相同的记忆过程的不同类型的刺激，即，简单的听觉，简单的视觉，和视觉刺激。在他们的任务中，设备，过程类型和大鼠是相同的，只有刺激类型不同。第三个实验比较了相同的m ...更多信息 记忆过程的不同方面的复合刺激，即，基本听觉，视觉记忆，和连续视觉记忆刺激。他们的任务采用相同的设备，过程类型，刺激类型和大鼠。在执行任务的过程中，记录海马结构（CA1，CA3和齿状回）单个神经元的活动。在每个实验中，一些记录的神经元在一个、两个或所有任务中表现出与任务相关的差异激活。这些结果表明，在多个记忆过程中的神经元的一些功能重叠。对同时记录的神经元之间的活动进行的交叉相关分析表明，在每个实验中，它们的一些功能性突触连接在任务之间发生了变化。这反映了突触连接在不同记忆过程中的动态变化。这些发现共同支持记忆过程的细胞组装编码。少

The plausible basic code for information processing of memory is the "cell assembly", i.e., overlapped populations of neurons with flexible functional connections within and among the populations. The present series of experiment has investigated two main properties of cell assemblies, that is, the overlapping of neurons and the dynamics of synaptic connections, in processing several different processes of memory.The first experiment compared different types of memory-process of identical stimuli, that is , Working memory and reference memory. In the tasks for them, the apparatus, stimuli and rats were identical and only the types of process required differed. The second experiment compared identical memory-processes for different types of stimuli, that is, simple auditory, simple visual, and configural auditory-visual stimuli. In the tasks for them, the apparatus, types of process and rats were identical and only the types of stimuli differed. The third experiment compared identical m … More emory-processes for different aspects of compound stimuli, that is, elemental auditory, configural auditory-visual, and successive auditory-visual stimuli. The tasks for them employed identical apparatus, types of process, types of stimuli and rats. Only the aspects of stimuli to be processed differed.Activity of individual neurons of the hippocampal formation (CA1, CA3 and dentate gyrus) were recorded during performance of the tasks. Some proportions of the recorded neurons showed task-related differential activation in one, two or all of the tasks in each experiment. These results indicate some functional overlapping of the neurons in multiple memory-processes. A cross-correlation analysis of activities among the simultaneously recorded neurons showed that some of their functional synaptic connections changed among the tasks in each experiment. This indicates the dynamic changes of synaptic connections in different memory-processes. These findings together support the cell-assembly coding of memory processes. Less