Analysis of functional neuron circuits underlying variability and reconstruction of long-term memory

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This study intended to experimentally investigate how brains form and use long-term memory, the memory retained for a long time once it is formed. Our concrete procedures were that we first developed original methods of electrophysiological recording and data analysis and then actually recorded and analyzed activities of multiple neurons when animals were forming and using long-term memory. The main results suggest that local circuits of neurons are formed and in active in the hippocampus and the prefrontal cortex when long-term memory has been formed and active. The results also suggest that broad circuits of neurons between the hippocampus and the prefrontal cortex are formed when contents of the memory have changed.