Genetic architecture and evolution of complex traits across populations

大多数人类特征都有遗传成分，并在种群内部和种群之间显示出大量的多样性。自然选择如何改变和维持人类特征的遗传变异是进化论中一个长期存在的问题，该计划旨在回答这个问题。利用创新的统计方法和最大的基因组“大”数据集，跨越不同祖先背景的人群，该项目期望产生关于自然选择在塑造性状遗传变异中的作用的新知识，并确定驱动人类群体分化的关键因素。这些结果将大大提高我们对人类特征进化和种群适应环境变化的理解。

Most human traits have a genetic component and display substantial diversity within and among populations. How natural selection changes and maintains genetic variation in human traits is a long-standing question in evolution that the proposed project aims to answer. Using innovative statistical methods and largest genomic “big” datasets ever across populations of different ancestral backgrounds, this project expects to generate new knowledge on the roles of natural selection in shaping the genetic variation in traits and identify key factors that drive the differentiation of human populations. These outcomes will significantly improve our understanding on the evolution of human traits and adaptation of populations to changing environments.