Study on spontaneous cleft lip and/or palate repressor-Pursuit of spontaneous repressor using human being and mice manifesting spontaneous cleft lip and/or palate-

1.我们使用旋转器官培养证实了在排除母体效应的环境下，食品中包含的大豆成分染料木黄酮和绿色茶成分儿茶素对腭裂发病率的预防作用。2.在我们使用旋转器官培养的实验之后，我们直接施用叶酸，维生素和黄体酮对母鼠的作用，并在“体内”和“体外”得到证实。3.我们已经在日本腭裂协会年会和日本畸形学会年会上报告了这些研究的结果。4.由于今年是本研究的最后一年，我们完成了我们的研究，阐明了自发性CLP抑制剂如雌二醇对心血管器官的影响，并以文章形式报道。

1.We confirmed preventive effect of genistein, which is the ingredient of soybean included in food, and catechin, which is the ingredient of green tea on the incidence of cleft palate under environment excluded maternal effect using revolving organ culture.2.Following our experiment using revolving organ culture, we directly administered folic acid, vitamin and progesterone to maternal mice and confirmed in both "in vivo" and "in vitro".3.We have already reported the results of those studies at Annual Meeting of the Japanese Cleft Palate Association and Annual Meeting of the Japanese Teratology Society. Also, those have been published.4.Since the current year is the last year for this study, we have rounded off our research, have clarified the influence of spontaneous CLP repressor such as estradiol on cardiovascular organ and have reported as articles.