Analysis of allergic march in children-especially in atopic dermatitis and bronchial asthma

(1)早产儿嗜酸性粒细胞为了阐明嗜酸性粒细胞在变应性疾病中的功能作用，我们研究了发生慢性肺部疾病的早产儿嗜酸性粒细胞。研究参数为外周嗜酸性粒细胞计数、嗜酸性粒细胞核数、嗜酸性阳离子蛋白（ECP）和气管内吸出物弹性酶活性。这些参数的纵向测定表明，嗜酸性粒细胞高度活化，并与慢性肺病的严重程度密切相关。(2)特应性皮炎（AD）患者的白细胞功能特应性皮肤是金黄色葡萄球菌（SA）的高度定植，SA产生的各种毒素可加重皮肤病变。与对照组相比，1岁以下AD患者白细胞吞噬活性降低，这被认为是导致SA持续皮肤感染的原因之一。而另一方面，2岁以上伴有皮肤干性损伤的AD婴儿往往有增强的过氧化氢生成，并且他们的白细胞似乎已经被启动。(3)酸性电解水减少特应性皮损中的金黄色葡萄球菌——一种治疗特应性皮炎的新策略，AD患者皮肤护理的重要性已被广泛认识，各种方法被采用，临床结果也各不相同。在我们的实验室中，酸性电解水被成功地应用于AD患者的皮肤护理，并显著减少了金黄色葡萄球菌。到目前为止没有发现不良反应。

(1) Eosinophilia in premature infantsIn order to help to clarify the functional role of eosinophils in allergic disorders, eosinophils in premature infants were studied who developed chronic lung disease. Parameters studied were peripheral eosinophil counts, number of nuclei of eosinophils, eosinophilic cationic protein (ECP) and elastase activity of intratracheal aspirates. Longitudinal determinations of these parameters indicated that eosinophils are highly activated and closely correlated to the severity of the chronic lung disease.(2) Leukocyte functions of patients with atopic dermatitis (AD)Atopic skins are highly colonized with staphylococcus aureus (SA), and various toxins which are produced by SA are known to aggravate the cutaneous lesions. Phagocytic activity of leukocytes of AD patients under 1 year of age was decreased when compared with controls, which is considered to be contributory to the establishment of persistent skin infection with SA.While on the other hand, AD infants over 2 years of age with dry skin lesions tended to have an enhanced hydrogen peroxide production, and their leukocytes appeared to have already been primed.(3) Reduction of Staphylococcus aureus in atopic skin lesions with acid electrolytic water - A new therapeutic strategy for atopic dermatitis Importance of kin care of AD patients is widely acknowledged, and various methods have been employed with various clinical outcomes. In our laboratory acid electrolytic water was successfully employed in skin care of patients with AD associated with a significant reduction of Staphylococcus aureus. No adverse reactions have been noted so far.