Possibility of new endstopic pbotodynamic therapy with ultrasound.

在过去的几十年里，超声波被广泛用于医学诊断和物理治疗。近年来，一些研究表明超声与化疗药物联合应用可增强细胞毒反应。利用超薄超声探头，研究了光敏药物Photofrin II在体外对低强度超声增强对结肠26细胞的急性杀伤作用。该探头的外径为2 mm，可插入普通内窥镜的仪器通道。单独的PHOTOFRIN II没有显示出明显的细胞杀灭作用，但单独的超声波显示出轻微的杀灭作用。超声与Photofrin II联合应用具有明显的细胞杀伤作用，提示超声内窥镜下光动力疗法的可行性。

Ultrasound has been used extensively over the last decades for medical diagnostics and physical therapy. Recently a number of reports have demonstrated enhanced cytotoxic responses when ultrasound and chemotherapeutic agents are combined.Enhancement of acute cell killing of colon26 cells by low-level ultrasound in the presence of the photosensitizing drug Photofrin II was examined by the use of ultra-thin ultrasound probe in vitro. The probe has an outer diameter of 2 mm and fits through the instrument channel of a common endoscope. Photofrin II alone showed no significant cell killing effect but ultrasound alone showed a slight that. The combined ultrasound and Photofrin II showed marked cell killing effect.These results suggest that the possiblity of the new endoscopic photodynamic therapy with ultrasound.