Efficacy of Vitamin B12 administration treatment for biological rhythm disorder in the totally blind person

在以前的研究中，大多数全盲者保持大约24小时的睡眠-觉醒时间表，即使他们的其他节律（褪黑激素，温度等）是自由运行的。有多少全盲者抱怨睡眠-觉醒节律紊乱。我进行了睡眠问卷调查的视力残疾人谁进入同一机构。调查对象216人，其中全盲84人，非全盲132人。全盲组与非全盲组的睡眠-觉醒障碍患病率差异无统计学意义。睡眠-觉醒时间表问题通常不会使全盲患者去看医生，因为大多数全盲患者都有很强的信息时间线索（社会线索）和自我平衡机制。维生素B12（VB 12）对睡眠时相延迟综合征和非24小时睡眠-觉醒综合征有效。我给一位患有多年不规则睡眠-觉醒模式的全盲患者服用了VB 12。此后不久，她的不规则睡眠-觉醒模式得到改善，她的总睡眠时间增加，觉醒次数减少。在施用VB之前，她的血清中的褪黑激素水平在全天期间显示低水平（低于10 pg/ml）。施用之后12天，她的褪黑激素水平在夜间增加至20 pg/ml。这些结果表明，褪黑激素水平可能是VB 12改善不规则图案的结果。

In previous studies, most total blind person maintain a roughly 24-hour sleep-wake schedule, even when their other rhythms (melatonin, temperature and so on) are free-running.How many do total blind person complain sleep-wake schdule disorder. I conducted a sleep questionnaire survey of sight handicapped person who were entering the same institution. The subjects were 216,84 of whom were total blind person and 132 were not total blind person. There was not significant difference in rate of prevalent sleep-wake schedule disorders among the total blind and the not total blind. Sleep-wake schedule problem dose not typically bring totally blind person to a physician, because most total blind person have strong information time cues (social cues) and homeostatic mechanisms.Vitamin B12 (VB12) in effective for delayd sleep phase syndrome and non-24-hour sleep-wake syndrome. I administered VB12 to a total blind patient suffering for many years from irregular sleep-wake pattern. Shortly thereafter, her irregular sleep-wake pattern has improved, her total sleep time has increased and her number of awaking has decreased. Her melatonin level in the serum showed low level (under 10pg/ml) during all day before administration of VB12.8 days after administration, her melatonin level has increased up to 20 pg/ml during the night. These results suggest that melatonin level may increased as the result of improvement in irregular pattern by VB12.