Association between prognosis and LOH in colorectal cancers

背景资料。本研究的目的是明确等位基因缺失与结直肠癌转移潜能的关系，并确定等位基因缺失是否可以作为判断结直肠癌患者预后的遗传标志物。应用聚合酶链式反应对80例原发结直肠肿瘤进行DCC杂合性缺失检查。采用多因素分析进行生存相关分析。DCC改变在转移潜能较高的原发肿瘤中更常见。虽然这些缺失与生存期或远处转移之间没有统计学意义的关联，但是移行细胞癌缺失的患者的存活率较低(p=0.056)。提示DCC的改变是获得结直肠癌转移潜能的关键遗传事件。然而，需要进一步的研究来利用这些基因改变作为有价值的预后标记物。

Background. The aim of this study is to define the association of allelic losses with the metastatic potential of colorectal carcinoma and to determine whether allelic losses can be genetic markers for the prognosis of patients with colorectal carcinoma.Methods. Eighty primary colorectal tumors examined for loss of heterozygosity at the DCC by using polymerase chain reaction. Association of survival was studied by multivariate analyssi.Results. DCC alterations were detected more frequently in primary tumors with higher metastatic potential. Although no statistically significant association was found between these losses and survival or distant metastasis, patients with DCC losses showed poorer survival (p=0.056).Conclusions. It was suggested that alterations of the DCC are critical genetic events for the acquisition of metastatic potential in colorectal carcinoma. However, further studies will be required to utilize these genetic alterations as valuable prognostic markers.