Electrically Induced Auditory Brainstem Response as a Clinical Tool in Explicating Sudden Deafness

(1)利用豚鼠耳蜗双极电极，可以很容易地获得听觉脑干电刺激反应（EABR）。(2)正常豚鼠在500muA电刺激下EABR出现5个不同的正峰，但EABR波形与ABR波形之间存在较大差异。(3) EABR至500muA的每个峰值延迟缩短约1msec。与ABR相比。(4)正常豚鼠EABR阈值平均为55muA，范围为20muA ~ 100muA。(5)插入电极记录EABR引起的耳蜗损伤导致ABR阈值上升8dB。(6)给药100mg/kg Frosemide不影响EABR记录中的任何潜伏期和阈值。(7)我们EABR记录的任何潜伏期和阈值在给药40mg/kg的卡那咪嗪14天后都没有受到影响。

(1)Auditory brainstem responses to electrical stimulation (EABR) could be easily obtained by using bipolar electrodes in cochlear of guinea pig.(2)EABR to 500muA electrical stimulation in normal guinea pig showed five different positive peaks, but EABR wave forms were much different in each other than ABR wave forms.(3)Each peak latencies of EABR to 500muA were shortened about 1msec. compairing from its of ABR.(4)The mean EABR threshhold in normal guinea pigs was 55muA,ranging from 20muA to 100muA.(5)Cochlear damages caused by inserting electrodes for EABR recording introduced 8dB ascending in ABR threshhold.(6)Any latencies and thresholds in our EABR recordings were not infruenced by administrating 100mg/kg Frosemide.(7)Any latencies and thresholds in our EABR recordings were not infruenced by administrating 40mg/kg Kanamicine for 14 days.