Experimental and clinical investigation on visual dysfunction in eyes with ischemic retinochoroidal disorders

临床上主要研究视网膜分支动脉阻塞。视野缺损表现为绝对暗点或灵敏度损失20 dB或更大。邻近Mariott暗点鼻侧水平线的每对上下测量点的灵敏度之间存在较大差异，这表明缺陷区域和正常区域之间存在直线边界。视网膜分支动脉阻塞患者合并心脏病或颈内动脉疾病的发生率高，易引起栓塞。在这些患者中经常观察到视网膜栓塞。栓塞的位置并不总是对应于闭塞部位。在伴有脉络膜新生血管的年龄相关性黄斑变性患者中，由于在初始激光治疗后6周或更短时间内拍摄的荧光素血管造影片检测到持续性或复发性脉络膜新生血管，许多眼睛需要进行第二次激光治疗，这表明在治疗这种疾病时需要定期进行仔细的荧光素血管造影随访。13EA02：用手术显微镜光源照射大鼠和兔眼视网膜和脉络膜血管，静脉注射虎红，造成实验性光动力血栓。使用视频荧光素血管造影和扫描检眼镜观察血管闭塞。明视视网膜电图显示振幅降低和峰潜伏期延迟。

Clincally the branch retinal artery occlusion was mainly investigated. The field defect showed either absolute scotoma or sensitivity loss by 20 dB or larger. A large difference between sensitivities in each pair of upper and lower measured points adjacent to the horizontal line nasal to Mariott's scotoma, which indicated a straight border between the defective field and the normal area. The patients with branch retinal artery occlusion showed high incidence of heart diseases or internal carotid artery disease that might cause embolism. Retinal emboli were often observed in these patients. The location of emboli did not always corresponded to the site of occlusion. In patients with age related macular degeneration with choroidal neovascularization many eyes needed second laser therapy due to persistent or recurrent choroidal neovascularization that was detected with fluorescein angiogram taken 6 weeks or less after the initial laser therapy, which suggests the need of careful follow-up with periodical fluorescein angiogram in the management of this disease. 13EA02 : Experimental photodynamic thrombosis was created by intravenous rose bengal injection followed by irradiation with a light source of surgical microscope in the retinal and choroidal vessels of rat and rabbit eyes. Vessel obliteration was observed using video fluorescein angiography with scanning ophthalmoscopy. Photopic electroretinogram showed amplitude reduction and delay in peak latency.