Cell adhesion of various ceramics

通过细胞计数和图像分析仪测量细胞相对粘附率，研究了Al_2O_3、ZrO_2、Si_3N_4、TiN和TiC等工程陶瓷的细胞粘附率。通过测量动态接触角和粘附细胞的百分比，还检查了通过加热氧化的钛和钛合金。五种工程陶瓷显示出与塑料培养皿一样好的细胞粘附性。钛及钛合金表面改性后，接触角减小，但对贴壁细胞百分率影响不大。随着切应力作用时间的延长，各条件下的贴壁细胞百分比均下降，表明工程陶瓷材料有可能作为生物材料。此外，表面改性的评估可能有助于检查材料表面的各个方面。

We investigated the cell adhesion rate of various engineering ceramics such as Al_2O_3, ZrO_2, Si_3N_4, TiN,and TiC by measuring the relative cell adhesion rate as assessed by a cell count and image analyzer. Titanium and titanium alloy that were oxidized by heating, were also examined by measuring the dynamic contact angle and the percent of adherent cells. Five kinds of engineering ceramics showed a cell adhesion as good as did plastic petri dishes. On the other hand, the surface modification of titanium and titanium alloys decreased the contact angle, but had only a small influence on the percentage of adherent cells. The percentage of adherent cells decreased in every condition with a longer application of shear stress.The results suggest that engineering ceramics may be of use as biomaterials. In addition, evaluation of the surface modification may be useful to examine aspects of the material surface.