SYNTHESIS OF RECEPTOR MOLECULES VIA NEW CHEMICAL METHODS

由于“分子识别”在生物膜运输、酶促反应和其他生物过程中起着重要作用，因此特异性受体的合成是当前化学中最令人兴奋的课题之一。尽管人工受体的种类很多，但其设计和合成都是“反复试验”的过程。本项目主要开展了非经验设计和高效合成特异性受体的研究工作，主要内容如下：（1）阳离子特异性受体的计算设计：通过计算机模拟优化了Na^+离子特异性武装大环化合物。（2）手性吡啶配体的高效合成：生物催化剂和有机金属化合物的联合合成以优异的产率提供了一系列新的手性寡吡啶配体。（3）阴离子特异性受体的一步合成：合成了一种新型的含四个吡啶阳离子的大环化合物，它具有高选择性的阴离子结合功能。

Since "molecular recognition" plays important roles in biomembrane transport, enzymatic reactions, and other biological processes, synthesis of specific receptors is one of the most exciting subjects in current chemistry. They offer excellent opportunities in investigating biological functions and developing supermolecular devices.Although many kinds of artificial receptors have been presented, their design and synthesis are "trial-and-error" exercises. We developed in this project non-empirical design and highly efficient synthesis of specific receptors as summarized below :(1)Computational Design of Cation-Specific Receptor : We optimized Na^+ ion-specific armed macrocycles by computational modeling.(2)Efficient Synthesis of Chiral Pyridine Podands : A combined synthesis with biocatalysts and organometallics offered a new series of chiral oligopyridine ligands in excellent yields.(3)One-Step Synthesis of Anion-Specific Receptors : A new type of macrocycle containing four pyridinium cations was readily prepared, which exhibited highly selective anion binding functions.