Epigenetic effects of environmental thyroid disruption

人为的影响越来越多地破坏了生态系统对环境变化的反应。该项目旨在确定气候变暖、夜间光照和塑料污染对甲状腺激素信号传导的相互作用影响，并测试这些影响是否在表观遗传学上代代相传。内分泌干扰的表观遗传效应是最重要的新兴保护威胁之一。实验数据的数学建模将有助于预测动物如何应对人为影响，并获得维持生态系统功能和服务所需的工具。因此，该项目将产生环境效益，以及国际合作和培训产生的社会效益。

Anthropogenic impacts increasingly disrupt hormone-mediated responses to environmental change. The project aims to determine the interactive effects of climate warming, light-at-night, and plastic pollution on thyroid hormone signalling, and test whether these effects are passed between generations epigenetically. Epigenetic effects of endocrine disruption are one of the most important emerging conservation threats. Mathematical modelling of experimental data will help to predict how animals respond to anthropogenic impacts, and to acquire the tools necessary to maintain ecosystem function and services. The project will therefore have environmental benefits, as well as social benefits stemming from international collaborations and training.