MEG-system with Optically Pumped Magnetometers (OPMs) (Teilfinanzierung)

该申请将申请资金用于购买脑磁图（MEG）系统，该系统由光泵磁强计（OPM）组成，用于在欧洲最大的大学医院之一Charité-Universitätsmedizin-Berlin测量临床和非临床人群的脑活动。目前，在Charité-Universitätsmedizin柏林没有meg系统。因此，这一建议解决了一个关键的空白，将关键性地推进精神病学和神经病学的研究。opm利用气相中的原子作为敏感的磁场探针来探测大脑的电活动。在过去的二十年里，opm传感器迅速发展，现在达到了与使用超导量子干涉器件（squid）的meg系统相似的灵敏度。重要的是，opm与传统SQUID-MEG系统相比有几个优势，因为opm可以在接近室温的情况下运行，而无需氦冷却。此外，opm可以比squid传感器更靠近头皮，从而改善信噪比，并便于儿科和临床人群的测量。这项申请的目标是与德国计量研究所（Physikalisch-Technische Bundesanstalt， PTB）一起建立一个领先的OPM-MEG设施，该研究所在OPM-MEG的开发方面拥有长期的专业知识，将这项技术应用于精神和神经疾病的理解、检测和治疗。OPM-MEG设施将被10个临床和基础研究小组用于精神病学（精神病、精神分裂症、自闭症谱系障碍）和神经系统疾病（帕金森氏病、癫痫）的研究，以及开发新的opm传感器和研究基本的大脑过程。最先进的OPM- meg系统将由96个OPM传感器组成，可以覆盖整个大脑，并检测大脑皮层和皮层下区域的神经活动。具体来说，预计位于Charité-Universitätsmedizin柏林的OPM-MEG设施将在开发用于早期检测和诊断脑部疾病的生物标志物方面取得关键进展，并推进对电路机制和新治疗方法的深入了解。

This application will request funds for the acquisition of a magnetoencephalographical (MEG) system consisting of optically pumped magnetometers (OPM) for the measurement of brain activity in clinical and non-clinical populations at Charité-Universitätsmedizin-Berlin, one of the largest university hospitals in Europe. Currently, a MEG-system is not available at Charité-Universitätsmedizin Berlin. Accordingly, this proposal addresses a crucial gap that will critically advance research into psychiatric and neurological conditions. OPMs utilize atoms in the gas phase that serve as sensitive magnetic field probes for electric activity of the brain. OPM-sensors have rapidly developed in the past two decades and now reach sensitivities similar to MEG-systems that employ Superconducting Quantum Interference Devices (SQUIDs). Importantly, OPMs have several advantages over traditional SQUID-MEG systems since OPMs can operate at near room-temperatures without helium cooling. Moreover, OPMs can be located closer to the scalp than SQUID-sensors, resulting in improved signal-to-noise as well as facilitating measurements in pediatric and clinical populations. The goal of this application is to establish a leading OPM-MEG facility together with the German Metrology Institute (Physikalisch-Technische Bundesanstalt, PTB), which has a long-standing expertise in the development of OPM-MEG, to apply this technology for the understanding, detection and treatment of psychiatric and neurological disorders. The OPM-MEG facility will be utilized by 10 clinical and basic research groups for studies into psychiatric (psychosis, schizophrenia, autism spectrum disorders) and neurological conditions (Parkinson’s Disease, epilepsy) as well as for the development of novel OPM-sensors and research into fundamental brain processes. The state-of-the-art OPM-MEG system will consist of 96 OPM sensors that allow whole-brain coverage and the detection of neural activity in cortical and subcortical brain regions. Specifically, it is expected that the OPM-MEG facility at Charité-Universitätsmedizin Berlin will allow critical advances in the development of biomarkers for early detection and diagnosis of brain disorders as well as advance insights into circuit mechanisms and novel treatments.