RISK FACTOR OF ORAL LICHEN PLANUS.-COHORT STUDY FOR FEMALE WITH LOW SERUM CAROTENOID LEVEL

马来西亚的一项关于口腔癌和癌前/癌前疾病患者血清中β-胡萝卜素的微量营养素的研究表明，血清微量营养素水平与口腔癌和癌前病变之间存在显著的负相关。为探讨血清类胡萝卜素水平与口腔扁平苔藓发病的关系，对日本某市日籍女性人群进行队列研究。1995年对3273名居民进行年度健康筛查，调查对象为934名40岁以上无病变、不吸烟的女性居民。分析血清β-胡萝卜素水平，并根据β-胡萝卜素水平将队列分为低、中、高三组。1996~1998年，在每年一次的口腔健康普查中检查口腔扁平苔藓的发生情况。检出口腔扁平苔藓低组1例，中组2例，高组3例。口腔扁平苔藓患者血清中任何一种微量营养素水平均无显著差异。提示低血清β-胡萝卜素水平与口腔扁平苔藓的发生无关。

A Malaysian study on serum micronutrients of beta -carotene on oral cancer and precancer/precancerous condition patients had shown significantly inverse associations between serum levels of micronutrients and oral cancer and precancer. The purpose of this study is to show the relationship between serum carotenoid levels and the occurrence of oral lichen planus by cohort study in Japanese female of a city in Japan.Nine hundred and thirty four female residents of over 40 years of age who were found without no lesion and no smoking were registered as an cohort during an annual health screening of 3273 residents as preliminary study in 1995. Serum beta -carotene was analyzed, and the cohort was divided into three groups according to the beta -carotene level ; low, middle and high level group. Occurrence of oral lichen planus was checked during an annual oral health screening for 3 years from 1996 to 1998.One case in the low group, 2 cases in middle group and 3 cases in high group were detected as positive oral lichen planus. There was no significant difference in any of the serum micronutrient levels among oral lichen planus cases. It is suggested that there was no relationship between low serum beta -carotene level and the occurrence of oral lichen planus.