Investigation of Anti-malarial Substances from Tropical Medicinal Plants

本研究以印尼民间常用的药用植物为研究对象，旨在从这些药用植物中寻找抗疟物质。结果，我们发现了以下有趣的发现。1）从马鞭草科Peronema canescens的叶片中分离得到一个新的克罗烷型二萜化合物，命名为peronemin A_2。2）从金荞麦树皮中分离得到一个新的酰胺化合物，命名为Hazaleamide（芸香科）和一种从Beilschmiedia madang木材中分离出的苄基异喹啉生物碱，名为dehatrine（樟科）表现出相同的活性。对40种印尼药用植物进行了初步筛选，确定了东革阿里（Eurycoma longifolia）根的水煎液（Simaroubaceae）对病原体恶性疟原虫（Plasmodium falciparum）显示出强烈的抗疟活性。

This research project used Indonesian medicinal plants which has been used as folk medicines in the country, and aimed at finding ant-malarial substances from them.As the result, we found interesting findings as following. 1)It had been found that a new clerodane-type diterpene named peronemin A2 isolated from the leaves of Peronema canescens (Verbenaceae) exhibits anti-malarial activity in vitro. 2)A new acid-amide named hazaleamide isolated from the bark of Fagara rhetza (Rutaceae) and a benzylisoquinoline alkaloid named dehatrine isolated from the wood of Beilschmiedia madang (Lauraceae) exhibit the same activity.Furthermore, the preliminary screening for forty kinds of Indonesian medicinal plants revealed the water decoction of the root of Eurycoma longifolia (Simaroubaceae) shows strongly the antimalarial activity against the pathogen Plasmodium falciparum.