Development of multiple channeled recording system for somatosensory evoked potendiuls by human dental stimulation

目的研制一种多强度随机电刺激体感诱发电位(SEPs)的新系统。本研究的目的是确定健康志愿者牙科刺激产生的3、4、6种不同强度的体感诱发电位是否与刺激强度相对应。电脑。该系统可以通过恒流等离线以随机的顺序自动生成8级强度的牙科仿真。获得知情同意的健康志愿者为受试者。这些受试者被分成三组。I组有3个强度等级。II组为4级，III组为6级。这项研究选择了一颗健康的、未充填的上中切牙。通过牙科电刺激从Cz处记录SEP。结果1)潜伏期在150~250ms的晚成分与刺激强度相对应；2)潜伏期在150~250ms的晚成分与疼痛强度的关系；3)刺激强度与疼痛强度的关系；4)该系统可以记录到多个刺激强度对应的SEPS波形。该系统有望用于评估镇痛剂或麻醉剂的止痛效果，阐明疼痛机制或心理变化。

PurposeWe developed a new system of recording somatosensory evoked potentials (SEPs) by randomized electrical tooth stimulation with multiple levels of intensity. The purpose of this study was to determine whether SEPs produced by the dental stimulation with 3, 4 and 6 different levels of intensity are recorded corresponding to stimules intensity in healthy volunteers.MethodsThe SEPs recording system is composed of SEps recording system, constant-current isolator and stimulator and . computer. The system can automatically generate the dental simulation with 8 levels of intensity through the constant-current isoiator at randomized order. Healthy volunnteers obtained informed consent were subjects. These subjects were divided into three groups. Group I had 3 levels of intensity. Group II and III were with 4 and 6. levlels of intensity respectively. A healthy, unfilled upper central incisor was selected fort' the study. SEPs were recorded from Cz through dental electrical stimulation. Sixty four evoked potentials were summed and averaged for each of the 3, 4 and 6 different intensity levels.Results1) The late component with a latency between 150 and 250 msec was corresponded to stimulus intensity in group I and II.2) The late component with a latency between 150 and 250 msec showed the relation with pain intensity in group I.3) The relation between stimulus intensity and pain intensity was observed.4) It was seggested that this system can be applied for clinical use.We could record SEPs wave form corresponded to multiple stimulus intensity using this systerm. The system is expected to be appropriate for evaluating the analgesic effects of analgesics or anesthetics and elucidating the pain mecanism or psychological changes.