Clinical Application of Visual Event-relatel Potentials using figures and letters

为探讨进行性核上性瘫痪(PSP)、皮质基底膜变性(CBD)、纹状体黑质变性(SND)和特发性帕金森病(PD)各16例的事件相关电位(ERPs)是否有特征性改变，我们对进行性核上性瘫痪(PSP)8例、皮质基底膜变性(CBD)10例、纹状体黑质变性(SND)9例和特发性帕金森病(PD)16例进行了研究。采用视觉古怪范式和延迟匹配(S 1-S2)范式诱发事件相关电位。将各组的ERPs和反应时(RT)与相应年龄匹配的正常对照组进行比较，并进行相互比较。PSP的P300波幅显著降低，而CBD的P300潜伏期延长，无论是Odball任务还是S1-S2任务。在古怪任务中，SND组和PD组均未发现P300异常。但在S1-S2任务中，PD组较SND组显著延迟N200，降低P300波幅。PSP组和CBD组的平均RT明显长于其他两组。这些结果不是由于年龄造成的。在两种任务中同时测量ERPs和RT可以提供有用的辅助信息，有助于根据临床和神经放射学标准诊断帕金森综合征。

Abstract In order to clarify whether there are characteristic changes of event-related potentials (ERPs) in parkinsonian syndromes, we studied 8 patients with progressive supranuclear palsy (PSP), 10 patients with corticobasal degeneration (CBD), 9 patients with striatonigral degeneration (SND), and 16 patients with idiopathic Parkinson's disease (PD) with a mean duration of illness of less than five years in each group. A visual oddball paradigm and a delayed matching (S 1-S2) paradigm were employed to elicit ERPs. ERPs and reaction time (RT) in each group were compared with those in the corresponding age-matched normal control group and to each other. In PSP, P300 amplitude was markedly reduced while in CBD P300 latency was prolonged during both the oddball and the S1-S2 task. No P300 abnormalities were found in the SND group or the PD group during the oddball task. However, significantly delayed N200 and reduced P300 amplitude during the S1-S2 task were found in PD but not in SND.The mean RT in the PSP and the CBD group was significantly longer than in the other two groups. These results were not due to age. Simultaneous measurement of ERPs and RT during two kinds of tasks may yield useful supplementary information in facilitating diagnosis of parkinsonian syndromes under clinical and neuroradiological criteria.