The Consteuction of the animal model for CTCL by SCID mouse

真菌样肉芽肿是一种皮肤T细胞淋巴瘤，临床上以表皮肥大为特征。它始于红斑期，恶性程度较低，并进展到肿瘤期，最终杀死宿主。目前尚无本病的实验动物模型，很难为动物的实验治疗模式构建一套分析本病发病机制的实验程序。我们的目的是通过对SCID小鼠ATL模型的修改，建立一种动物模型。将真菌病患者皮肤中的恶性T细胞静脉注射到SCID小鼠体内。移植的恶性T细胞在SCID小鼠体内存活。在淋巴结、衬里、脾和皮肤中可观察到集落形成。皮损未见真皮内单纯肿块形成，但有表皮趋向性。Pautrie‘s微型脓肿是真菌病的组织病理学特征，也在动物模型中观察到。根据这些数据，我们得出结论，该动物模型模拟了真菌病。

Mycosis fungoides is a cutaneous T cell lymphoma with clinical characteristics of epidermal manifistation. It starts as an erythematous stage which shoes poor malignancy and progress to the tumor stage and finaly kills the host. There was no experimental animal model of this disease, thus it was difficult to constract an experimental procedure for the analysis of pathomechanism of this disease for the experimental treatment model in the animals. Our purpose was the establishment of an animal model by modify of ATL model in the SCID mouse. The malignant T cell from the Mycosis Fungoides patient skin was injected intravenous in the SCID mouse. The transplanted malignant T cell survive in the SCID mouse. Colony formations were observed in the lymphnodes, liner, spleen and skin. The skin lesion was not constracted with simple mass formation in the dermis, but it showed the epidermotropism. Pautrie's microabcess which is a histopathological character of Mycosis Fungoides was also abserved in thei animal model. From these data, we concluded that this animal model mimic the Mycosis Fungoides.