Search for Asymmetric Catalytic Reactions using Low-valent Zirconium Complex

在我们正在进行的利用低价茂锆络合物进行不对称催化反应的研究项目中，我们开发了低价锆络合物--茂锆丁烯络合物用于有机合成的巨大可能性。在过去的项目期间，我们建立了几个新的新的茂锆丁烯络合物介导的合成方法，这些方法必须详细说明是催化的和不对称的。目前，我们已开发出一种新型的茂锆丁烯络合物催化的乙烯基环丙烷衍生物的开环反应，其化学计量反应已应用于立体控制的甾体侧链的合成。虽然这些反应的不对称版本还没有成功，但我们目前正在继续研究，寻找对锆金属络合物最有效的手性配体。

In our ongoing research project on asymmetric catalytic reactions using low-valent zirconocene complex, we have exploited enormous possibilities of low-valent zirconium complex, zirconocene-butene complex, for organic synthesis. During the past term of the project we established several new zirconocene-butene complex-mediated synthetic procedures which must be elaborated to be catalytic and asymmetric. At present we could developed a new zirconocene-butene complex catalyzed ring opening reactions of vinyl cyclopropane derivatives whose stoichiometric reactions have been applied to stereocontrolled syntheses of steroidal side chains. Although the asymmetric version of these reaction has not been succeeded yet, we are currently continueing the research to find the most effective chiral ligand for zirconium metal complex.