RESEARCH ON NEW SKELETAL NATURAL PRODUCTS AFFECTING THE CENTRAL NERVOUS SYSTEM

1.在小鼠强迫游泳实验中，Valerianaceae中国苦竹根茎的甲醇提取物具有较强的抗抑郁活性。萃取物被分级，由活性监测。从活性馏分中合成5个新的含愈创木碳骨架的倍半萜类化合物。它们的结构，包括立体化学，通过它们的光谱数据得到了阐明。倍半萜类化合物的抗抑郁活性等药理活性目前正在进行中。为了从天然来源中寻找抗帕金森病药物，开发了有价值的筛选方法。因此，杆状试验和惊厥试验在评价抗精神病药治疗动物运动障碍的药物方面具有一定的价值。从香菇Sarcodon scabrosus中分离得到新的胞烷型二萜类化合物，并通过二维核磁共振技术和化学转化等波谱方法确定了其结构。它们具有刺激神经生长因子(NGF)合成的活性。此外，生物学研究表明，二萜类化合物可导致人脑星形细胞瘤细胞与神经生长因子一起分泌其他因子。

1. A methanol extract of the rhizomes of Nardostachys chinensis belonging to Valerianaceae showed strong antidepressant activity in the forced swimming test using mice. The extract was fractionated, monitored by the activity. to afford five novel sesquiterpenoids bearing guaiane carbon skeleton from the active fractions. Their structures including stereochemistry were elucidated by their spectroscopic data. Pharmacological acticities such as antidepressant activity of the sesquiterpenoids are now in progress.2. For the purpose of the search of anti-parkinsonian agents from natural sources, valuable screening method was developed. As a result, pole test as well as catalepsy test is of value in the evaluation of drugs against motor disturbances in neuroleptic-treated animals.3. Novel cyathane-type diterpenoids were isolated from the mushroom, Sarcodon scabrosus and their structures were determined by spectroscopic method such as two dimensional NMR techniques and chemical transformation. They exhibited stimulating activity of the synthesis of a nerve growth factor (NGF). Moreover, biological study showed that the diterpenoids cause the secretion of other factors along with NGF from human astrocytoma cells.