Characterization of leptin's antidepressant activity

瘦素抗抑郁活性的表征

• 批准号: 7343154
• 负责人: Xin-Yun Lu
• 金额: $ 31.03万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-25 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7343154
• 关键词: Address; Adipocytes; Adipose tissue; Adult; Adverse effects; Affect; Anhedonia; Animal Model; Animals; Antidepressive Agents; Area; Behavior; Behavioral; Body Weight; Brain; Cell Proliferation; Chronic; Class; Depressed mood; Depressive disorder; Desire for food; Disruption; Emotional; Functional disorder; Genetic; Goals; Hippocampus (Brain); Hormones; Hypothalamic structure; Infusion procedures; Knock-out; Knowledge; Leptin; Link; Mediating; Mental Depression; Mental disorders; Modeling; Neurobiology; Neurons; Neurotransmitters; Pathogenesis; Patients; Phenotype; Play; Population; Predisposing Factor; Process; Regulation; Research Personnel; Role; Selective Serotonin Reuptake Inhibitor; Serotonin; Signal Transduction; Standards of Weights and Measures; Stress; Swimming; System; Testing; Therapeutic Effect; base; insight; leptin receptor; neurogenesis; neuromechanism; neurotransmission; novel; novel therapeutics; peptide hormone; programs; receptor; response

DESCRIPTION (provided by applicant): Depression is one of the most common mental illnesses. However, the pathogenesis and underlying neurobiology of depression remain poorly understood and not all depressed patients respond to current available treatments. Our recent studies have identified a role for leptin a hormone secreted from adipose tissue, in emotional processes and demonstrated that leptin has the potential as a novel antidepressant. The goal of this project is to elucidate the neural mechanisms underlying the antidepressant-like effects of leptin. First, we plan to investigate the potential role of leptin in hippocampal neurogenesis. Second, the importance of leptin action on the hippocampus in emotional behaviors will be addressed using both pharmacological and genetic approaches. Third, we will investigate the functional interaction between leptin and the serotonergic system. Our main hypothesis is that leptin's antidepressant-like activity is mediated by specific brain circuits and neurotransmitters. These studies will contribute to mechanistic understanding of the role of leptin in depression and provide insights into novel therapeutic approaches for the treatment of depressive disorders.

描述（由申请人提供）：抑郁症是最常见的精神疾病之一。然而，抑郁症的发病机制和潜在的神经生物学仍然知之甚少，并不是所有的抑郁症患者都对现有的治疗方法有反应。我们最近的研究已经确定了瘦素（一种由脂肪组织分泌的激素）在情绪过程中的作用，并证明了瘦素有可能成为一种新的抗抑郁药。该项目的目的是阐明瘦素抗抑郁作用的神经机制。首先，我们计划研究瘦素在海马神经发生中的潜在作用。其次，瘦素在情绪行为中对海马体作用的重要性将通过药理学和遗传学方法来解决。第三，我们将研究瘦素和血清素能系统之间的功能相互作用。我们的主要假设是瘦素的抗抑郁活性是由特定的脑回路和神经递质介导的。这些研究将有助于了解瘦素在抑郁症中的作用机制，并为抑郁症的治疗提供新的治疗方法。