Evaluation of oxygen toxicity by Hyperbaric Oxygen Therapy (HBO)

氧气毒性已经成为对使用氧气治疗的关键点，除了经典毒性，如保罗·本特或劳伦·史密斯的效应。氧气是非常有用的，我们认为它是一种有用的治疗，作为一种次要的治疗，尽管如此，并没有用Hyperbaric氧气疗法来清除氧气毒性（HBO）解决了自Beraema 1960年以来一直流行的一项被称为没有血液的生活的建议。本研究是如何估计氧气自由基物在等离子体中的变化，即一个指标，即对氧气毒性的指标。我们成功地利用Erectro spin trapping resonance （ESR）捕获羟基激进分子。羟基-激进分子一直在跟踪，不仅是动物实验，而且是HBO患者的临床数据。事实上，它估计HBO的关键水平是3ATA 60分钟暴露纯氧和羟基的价值必须成为正常水平，而且不能返回到HBO之前的正常水平。这表明我们在高压条件下的氧气呼吸剂量。我们还找到了超氧化物歧化酶（SOD）的活性，并显示了我们的HBO表指数，当患者必须被要求在HBO的应用中使用时。

Oxygen toxicity has been a critical point against the using oxygen for the therapy except classic toxicity like as Paul Bent or Laurain Smith effect. Oxygen is so useful for ishemic tissues and we consider it as an useful treatment as subsidiary one.While, there have not been made clear the oxygen toxicity concerned with Hyperbaric oxygen Therapy (HBO) though it has been popular since Beraema's proposal of so called life without blood in 1960.This research is how to estimote the changes of oxygen free radicals in plasma as an indicator against oxygen toxicity. We have succeeded to trap hydroxyl-radical by 5・5-dymethl-N-oxide (DMPO) using Erectro spin trapping resonance (ESR). Hydroxyl-radicals have been followed through not only animal experiments but clinic data from HBO patients. Eventually, it estimates that the critical levels of HBO is 3ATA 60minutes exposure by pure oxygen and Hydropxyl radicals values must becomes and not return to normal lebels before HBO.This indicates us the dose of oxygen breathing under high pressure conditions. We have also found the activity of superoxide dismutase (SOD) and this reserch shows us am index of HBO tables when the patients must be demanded the application of HBO.