Investigating non-canonical RNA processing in developing spermatids

RNA结合了DNA的信息含量和蛋白质的物理特性。这些特征意味着它正在成为新知识的主要参与者；寻找生物学基本问题的答案，以及生物技术的应用。该项目旨在了解非规范RNA加工事件如何控制基因表达。mRNA如何在转录后进行选择性储存、翻译、稳定或衰减以控制发育。rna驱动的过程控制着精子的形态发生和分化，但其机制尚不清楚。揭示广泛的细胞质聚腺苷化的功能，这是小鼠生育所必需的，可能会推动RNA生物技术应用的下一波浪潮。

RNA combines the information content of DNA and the physical properties of proteins. These features mean it's emerging as a major player for new knowledge; for answers to fundamental questions in biology, and for applications in biotechnology. This project aims to understand how non-canonical RNA processing events control gene expression. How mRNA is processed post-transcriptionally for selective storage, translation, stabilisation or decay to control development. RNA-driven processes program morphogenesis and differentiation of spermatids, but via mechanisms only poorly understood. Uncovering the function of extensive cytoplasmic polyadenylation, which is essential for murine fertility, may fuel the next wave of RNA biotech applications.