Gut Absorption of Constrained Peptides for Local and Systemic Targeting

目的：本项目旨在通过生物分析和药代动力学与高分辨率显微镜和成像相结合的方法，在啮齿动物模型中研究多肽是如何通过肠壁吸收并分布到器官和液体中的。 意义：该项目希望通过实施创新的方法，对多肽吸收、生物分布和免疫细胞靶向的途径和机制进行迄今为止最全面的调查。 预期结果：预期结果包括重要的新知识和衡量多肽吸收的新的多学科平台。 好处：这将为补充剂、治疗药物和载体的未来多肽设计提供信息，从而提供显著的好处。

Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging. Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by implementing innovative approaches. Expected Outcomes: Expected outcomes include significant new knowledge and a new multi-disciplinary platform for measuring peptide absorption. Benefits: This should provide significant benefits by informing the future design of peptides for supplements, therapeutics and carriers.