Neural mechanisms of trigeminal rhythmical activities

我们分析了三叉神经回路与有节奏的下颌运动有关。我们使用了新生大鼠。采用体外离体脑干阻滞制备和全细胞膜片钳技术。结果如下：1。我们在三叉神经运动神经元的膜电位上发现了节律性EPSP，认为它起源于节律发生器。n -甲基d -天冬氨酸（NMDA）受体激动剂的应用诱导了这些epsp。NMDA受体必须参与节律产生回路。在胚胎期，E-20产生三叉节律活动。在e -18,19中，节奏活动不完全被识别。然而，有节奏的epsp是经常被识别的。在e -16,17中，没有产生节奏活动。节律产生电路很可能在e -18,19发育。

We analyzed the trigeminal neural circuit related to rhythmical jaw movements.We used neonatal rats. We used in vitro isolated brainstem block preparation and whole cell patch clamp technique. Results as follows1. We found rhythmical EPSP on membrane potentials of trigeminal motoneurons, which were thought to be originated from rhythm generators.2. N-methyl D-aspartate (NMDA) receptor agonist, NMA application induced those EPSPs. NMDA receptor must be involved in the rhythm generation circuit.3. In embryonic stages, trigeminal rhyrhmical activities were generated in E-20. In E-18,19, the rhythmical activities were incompletely recognized. However, rhythmical EPSPs were regularly recognized. In E-16,17, the rhythmical activities were not generated. It is likely that the rhythm generation circuit is developed at E-18,19.