Biological regulation of orthodontic tooth movement, anchorage and retention

目前的研究目的是调查转化增长因子-β1 （TGF -β1）、1，25-二羟基维生素D 2， 24，25-二羟基维生素D 3在实验性牙齿运动后的反应。55只Sprague Dawley老鼠， 6周老了，已经被用于这个实验。那个上第一摩尔被一个戒指平均移动了20磅的强度。这大约需要48天才能完成1毫米的运动。这些装置被搬走了。10伊D1 - 10伊D1 - 10伊D1-9伊D1 mol/L1，25-dihydroxyvitamine D 23伊D2， 10伊D1-8伊D1 - 10伊D1-5伊D1 mol/L24，25-dihydroxyvitamine D D23伊D2 or 0.2 ~ 20 ng/ml TGF -β1 was injected into the subperiosteum of upper first molar of animals of experimental groups every two days for 14 days。注射在2天前启动，以清除该设备，并在清除后继续进行，直到12天。24，25-二羟基维生素D23-D2治疗组和TGF -β1治疗组在实验后的反应中显示出抑制效应 ... More 与PBS治疗组比较的运动。PBS治疗组在12天后释放了0.60 mm，同时10 mm D1-5 mm D1 mol/L24，25-二羟基维生素D23 mm D2治疗组显示了0.31 mm和2 ng/ml TGF -β1治疗组显示了0.38 mm相对，反应。1，25-二羟基维生素D-23-D2治疗组和PBS治疗组之间没有明显的差异.骨骼组织学上，在24，25-二羟基维生素D-D23-D2治疗组和TGF -β1治疗组之间的压力方面， BV/TV和Ob. S/BS是一个有意义的大的，而Oc. S/BS和No. Oc/BS在12天后被拆除的PBS处理的团体明显小于该装置。在24，25-二羟基维生素D-23-D-2治疗组和TGF-β1治疗组的张力方面， BV/TV和Ob. S/BS明显大于PBS治疗组的张力方面。BV/TV、Ob. S/BS、Oc. S/Bs和No. Oc/BS在压力和张力方面的两个方面之间没有明显的区别。这些结果建议24，25-dihydroxyvitamine D23-D2和TGF -β1在实验性牙齿运动后，抑制了Alveolar骨骼的骨骼分解和刺激性骨骼的形成，并且在预防正当性复发时可能会有用。Less（低）

The purpose of the present study was to investigate the effect of transforming growth factor-β1 (TGF -β1), 1, 25-dihydroxyvitamine DィイD23ィエD2, 24, 25-dihydroxyvitamine D3 on relapse after experimental tooth movement in rats. Fifty five Sprague Dawley rats, 6 weeks old, were used for this experiment. The upper first molar was moved mesially with the magnitude of 20 gf exerted by a ringlet. It took about 48 days to obtain 1mm movement. The appliance them removed. 10ィイD1-10ィエD1〜10ィイD1-9ィエD1 mol/L 1, 25-dihydroxyvitamine DィイD23ィエD2, 10ィイD1-8ィエD1〜10ィイD1-5ィエD1 mol/L 24, 25-dihydroxyvitamine DィイD23ィエD2 or 0.2〜20ng/ml TGF -β1 was injected into the subperiosteum of upper first molar of animals of experimental groups every two days for 14 days. Injection was initiated on 2 days prior to removal of the appliance and continued till 12 days after the removal. 24, 25-dihydroxyvitamine DィイD23ィエD2 treated group, and TGF -β1 treated group showed suppressive effects on the relapse after experimental too … More th movement compared with PBS treated group. The PBS treated group exhibited 0.60 mm relapse on 12 days after removal of the appliance, while 10ィイD1-5ィエD1 mol/L 24, 25-dihydroxyvitamine DィイD23ィエD2 treated group showed 0.31 mm and 2 ng/ml TGF -β1 treated group showed 0.38 mm relapse, respectively. However, there was no significant difference between 1, 25-dihydroxyvitamine DィイD23ィエD2 treated group and PBS treated group.Bone histomorphometrically, on the pressure side of the interradicular septum in 24, 25-dihydroxyvitamine DィイD23ィエD2 treated group and TGF -β1 treated group, BV/TV and Ob.S/BS were significantly larger, and Oc.S/BS and was No.Oc/BS were significantly smaller than those of PBS treated group on 12 days after removal of the appliance. On the tension side in 24, 25-dihydroxyvitamine DィイD23ィエD2 treated group and TGF-β1 treated group, BV/TV and Ob.S/BS were significantly large , and No.Oc/BS was significantly smaller than those of PBS treated group. There was no significant difference between 1, 25-dihydroxyvitamine DィイD23ィエD2 treated group and PBS treated group in BV/TV, Ob.S/BS, Oc.S/Bs, and No.Oc/BS on both pressure and tension sides.These results suggest that the 24, 25-dihydroxyvitamine DィイD23ィエD2 and TGF -β1 inhibit bone resorption and stimulate bone formation of the alveolar bone during relapse after experimental tooth movement, and could be useful in preventing the orthodontic relapse. Less