The study of the control mechanisms of gastric motility and the change after function preserving operation.

The study designed to analyze canine gastroduodenal motility using strain gauge forcetransducers （SGTs）或barostat， and to clarify the motility control mechanismsespecially the pylorus and the fundus.We established the method to evaluate the canine pyloricopening using the SGTs. the relaxation and opening of the pyloric ring was observed synchronously使用intense construction of the antrum during the phase III of normal dogs. As the same manner，phase ii -like motility, which was not a typical periodic motilitywas observed in the - pylorus-preserving pancreatoduodenectomy (PPPD) dogs. the phase ii -likemotility was induced by Leu D113 motilin在both normal and PPPD dogs. Therefore.Leu D113 D1-motilin must improved dysmotility of the pylorus after pppdd . we also clarified the rolecholinergic和nitrergic inputs in mechanically and chemically induced gastric relaxation in cholinergic和nitrergic inputs in mechanically and chemically induced gastric relaxation inconscious dogs. When mechanical刺激insufflating the intragastric bag at constant rate，the recordings of barostat showed the steep linear increase in intragastric pressure to about 6mmHg. After that，the pressure had continued to increase gradually. N - 1-monomethyl- l- arginine acetate （L-NMMA）increased the pressure/volume gradient一个简单的意图lipid as chemical stimulation rapidlyincreased the proximal gastric volume(150.0±50.2ml). Although the lipid-induced increase in gastricvolume subsided after atropine i.v.(36.0±14.7 ml；p < .5),它没有使用treatment - nmma(167.6±3.0ml). The study shows that nitrergic input is不需要chemically induced gastric relaxation，但这是必要的，因为mechanically induced one. On the other hand，连续cholimergic input is必要性for the both。

The study was designed to analyze canine gastroduodenal motility using strain gauge force transducers (SGTs) or barostat, and to clarify the control mechanisms of the motility, especially the pylorus and the fundus.We established the method to evaluate the canine pyloric opening using the SGTs. The relaxation and opening of the pyloric ring was observed synchronously with intense construction of the antrum during the phase III of normal dogs. As the same manner, phase III-like motility, which was not a typical periodic motility, was observed in the - pylorus-preserving pancreatoduodenectomy (PPPD) dogs. The phase III-like motility was induced by LeuィイD113ィエD1-motilin in both normal and PPPD dogs. Therefore. LeuィイD113ィエD1-motilin must improved dysmotility of the pylorus after PPPD.We also clarified the role of cholinergic and nitrergic inputs in mechanically and chemically induced gastric relaxation in conscious dogs. When mechanical stimulation, was applied by insufflating the intragastric bag at constant rate, the recordings of barostat showed the steep linear increase in intragastric pressure to about 6 mmHg. After that, the pressure had continued to increase gradually. NィイD1GィエD1-monomethyl-L-arginine acetate (L-NMMA) increased the pressure/volume gradient, while atropine reduced it significantly. An oral intake of lipid as chemical stimulation rapidly increased the proximal gastric volume (150.0±50.2ml). Although the lipid-induced increase in gastric volume subsided after atropine i.v. (36.0±14.7 ml ; p<0.005), it was unaffected by treatment with L-NMMA (167.6±53.0ml). The study shows that nitrergic input is not necessary for chemically induced gastric relaxation, but it is necessary for mechanically induced one. On the other hand, continuous cholimergic input is necessary for the both.