Molecular mechanism for the low invasiveness of laparoscopic surgery

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We investigated the molecular mechanism for the low invasiveness of laparoscopic surgery. 1. Portal vein blood pH, hepatic function, and hepatic histology were disturbed in a porcine carbon dioxide pneumoperitoneum model. It may be necessary to pay attention to liver damage during laparoscopic surgery. 2. Post operative adhesions were suppressed in rat pneumoperitoneum model compared to open surgery. Plasminogen activator inhibitor-1 (PAI-1) level, which is a key molecule for post operative adhesion formation, was suppressed in serum and peritoneal lavage in pneumoperitoneum model. The PAI-1 mRNA level measured from rat and human omentum were also suppressed, which implied the mechanism of reduction for postoperative adhesions in laparoscopic surgery.