Electrophysiological study on the antinociceptive effect of xenon.

Xenon （Xe） suppresses wide dynamic range （WDR） neurons in cat spinal cord to a similar extent as nitrous oxide （N-D22-D2O）。The antinociceptive action of N-D22-D2O involves the descending inhibitory system。在订购时，当降低的抑制系统也被纳入Xe的反氧化作用中，我们比较了Xe上的影响与那些N-D22-D2 O在spinal cord transected cats anesthetized with α-chloralose和urethane相比。我们调查了WDR神经元对触摸和捏的变化的反应。70%的Xe在所有12个神经元中都有明显的抑制性触摸和刺痛性的反应。在对比度中， 70% N-D22-D2 O没有显示有意义的抑制在两个触摸和收缩响应。这些结果建议说，Xe可能不是由下降的抑制剂系统引起的，但可能会产生对脊柱角神经元的直接影响。

Xenon (Xe) suppresses wide dynamic range (WDR) neurons in cat spinal cord to a similar extent as nitrous oxide (NィイD22ィエD2O). The antinociceptive action of NィイD22ィエD2O involves the descending inhibitory system. In order to clarify whether the descending inhibitory system is also involved in the antinociceptive action of Xe, we compared the effects of Xe on the spinal cord dorsal horn neurons with those of NィイD22ィエD2O in spinal cord transected cats anesthetized with α-chloralose and urethane. We investigated the change of WDR neuron responses to touch and pinch by both anesthetics. 70% Xe significantly suppressed both touch-and pinch-evoked responses in all 12 neurons. In contrast, 70% NィイD22ィエD2O did not show significant suppression in both touch-and pinch-evoked responses. These results suggest that the antinociceptive action of Xe might not be mediated by the descending inhibitory system, but instead may be produced by direct effect on spinal dorsal horn neurons.