Research about rehabilitation of motor disability by using the magnetic stimulation

重复性经颅磁刺激(RTMS)对抑郁状态的作用已有报道。1998年，我们在正常小鼠身上研究了rTMS的安全性和临床实用性。将小鼠分为三组，分别以130%和90%的运动阈值强度对小鼠进行rTMS刺激(组I：rTMS在10赫兹作用10s，组II：rTMS在3 Hz作用60s，组III：非rTMS)。RTMS后，采用Morris水迷宫实验评价rTMS对小鼠学习记忆能力的影响。I组和II组小鼠的学习记忆能力较弱，但rTMS的作用是一过性的。我们认为rTMS在上述强度、频率、磁刺激序列和每个磁刺激序列的间隔时间内是安全的。1999年，我们尝试利用磁刺激来研究人二头肌的收缩模式。测量收缩模式的收缩时间和松弛时间。男性和女性的收缩时间没有差异，但女性的一半松弛时间长于男性，这一差异认为快慢抽动单位的比例可能不同于男性。接下来，我们通过50赫兹的重复磁刺激0.5秒来检查强直性收缩。重复磁刺激后单次抽动的抽动张力大于训练前的抽动张力。这被认为是破伤风后的增强作用。对人体重复磁刺激是分析人体近端肌肉收缩模式的一种有效而简便的方法，可能具有临床应用价值。

The rTMS (repetitive transcranial magnetic stimulation) was reported the effect for depression state. In 1998, we studied the safety and the clinical usefulness of rTMS using normal mice. We divided three groups and stimulated the mice by rTMS (group I : rTMS at 10Hz for 10sec, group II : rTMS at 3Hz for 60sec, group III : non-rTMS) using the intensity of two types : 130% and 90% of motor threshold. After rTMS, we evaluated about the learning and the memory of the mice received rTMS, using Morris's water maze test. The mice of group I and group II seemed to be lower in the learning and the memory, but the effects of rTMS was transient. We thought that the rTMS was safe in above intensity, frequency, train of magnetic stimulation and the interval of each train of magnetic stimulation.In 1999, we tried to study the contraction patterns of human biceps brachii muscle using magnetic stimulation. We measured contraction time and relaxation time of the contraction patterns. The contraction time between male and female was no different but the half relaxation time of female was longer than that of male, This difference was thought that ratio of fast twitch unit and slow twitch unit might be different between male and female. Next, we examined tetanic contraction by repetitive magnetic stimulation of 50Hz for 0.5sec. The twitch tension of single twitch after train of repetitive magnetic stimulation was larger than the twitch tension before the train. This was thought to be post-tetanic potentiation. Repetitive magnetic stimulation to human was a useful and simple method to analyze the pattern muscular contraction of human proximal muscles and might be clinically applicable.