Gene Expression Program for Histological Reconstruction : Fibrogenesis induced pericellular fibrosis in rat liver, suppressed metastasis in human carcinomas

维生素C促进酒精性肝纤维化大鼠肝纤维化过程中Profilin、胶原和弹性蛋白基因的表达模糊集混沌算法(FSCA)使得调节分子的模糊ON/OFF重复等组织学成为可能。Pro、Gly和Cys的蛋白质表达编程加强了VC、VB1、Ca^&lt；2+和Gt；诱导的纤维化。蛋白质表达编程是为了减少补充t-RNAs对核糖体的翻译空闲，通过靶向HERE胶原蛋白中的特定蛋白质。对于基因表达编程，我们使用的ON命令是1)抗坏血酸(VC)合成胶原蛋白，2)通过提供胶原丰富的食物增加胶原mRNA的翻译，3)通过结合胶原和弹性蛋白(由钙激活)包裹转移的癌细胞，以及4)在纤维化形成过程中通过硫胺素(VB1)、核黄素(VB2)、吡哆醇(VB6)和钴胺(VB12)促进成纤维细胞的增殖。消除单个分子的供应构成了关闭的命令。这些指令是通过血流传递的；它们可能传递到感兴趣的区域，因为缓激肽、血管内皮生长因子、前列环素、血小板激活因子等增加了转移癌细胞周围血管壁的通透性。转移癌细胞周围的细胞因子和趋化因子用于通知成纤维细胞转移癌细胞的位置。CT扫描证实包络成功，并根据患者的生存能力判断治疗的有效性。肝纤维化GEP包膜转移性癌细胞在人体内的有效率为92%。一名携带印戒细胞的硬化性胃病患者已经被抑制了7年。用过的清蒸小鱼(SF)丰富了ALA。ALA增加了肝脏细胞周围的纤维化，相当于我们的程序图像中包膜转移的癌细胞。

Vitamin C increased the gene expression of profilin, collagen and elastin during fibrogenesis in alcoholic rats. Fuzzy Set Chaos Algorithm (FSCA) made it possible to regulatehistology such as fuzzyON/OFF repeats of regulatormolecules. Fibrosis byVC, VB1, Ca^<2+>wasreinforced by protein expression programming by Pro, Gly and Cys. Protein expression programming was performed to reduce translational idling on ribosome from supplement of t-RNAs, by targeting specific protein in here collagens. For the Gene Expression Programming, the ON commands we used were 1) synthesize collagens by ascorbic acid (VC), 2) increase collagen mRNA translation by supplying collagen-enriched food, 3) envelopmetastasized cancer cells by combining collagen with elastinwhich is activated by calcium, and 4) proliferate fibroblastic cells by thiamin (VB1), riboflavin (VB2), pyridoxine (VB6), and cobalamin (VB12) during the fibrogenesis. Elimination of the supply of individual molecules constituted the OFF command. The commands were transmitted via the blood flow ; their delivery to the area of interest was possible because permeability of the walls of blood vessels around metastasized cancer cells is increased by bradykinin, VEGF, prostacyclin, platelet activating factor etc. Cytokines and chemokines around metastasized cancer cells served to inform fibroblasts of the location of metastasized cancer cells. Successful enveloping was confirmed by CT-scans and the effectiveness of the therapy was judged by patient viability. GEP for fibrogenesis appjied to envelope the metastasized cancer cells ran effectively in human (92%). A scirrhus stomach patient carrying signet ring cells have been suppressed for 7 years. Used SF (steamed small fishes) enriches Ala. Ala increased pericellular fibrosis in liver equivalents our program image of envelopment metastasized cancer cells.