The familial study on Behcet's disease associated with HLA- B51 and another genetic factor

1.本文对家族性白吉特病（BD）进行了调查，结果如下：（1）收集到83例BD患者，其中男性41例，女性42例。(2)HLA-B51阳性率为53.1%（男性58.8%;女性46.7%）。（3）眼部病变与HLA-B51呈高度正相关，与生殖器溃疡呈高度负相关。有眼部症状者平均发病年（1973.3 ± 10.15）年低于无眼部症状者（1981.3±8.78）年。(4)1980年以后发病的患者中，完全型和有眼部症状的患者比例明显低于1979年以前发病的患者.印度尼西亚人云母基因微卫星分型结果。(1)127例受试者的云母基因型频率如下：A9/9为14.1%，A9/6为5.5%，A9/5（5.1）为28.3%，A9/4为11.0%，A6/6为1.5%，A6/5（5.1）为1.5%，A6/4为0.79%，A5（5.1）/5（5.1）为22.0%，A5（5.1）/4为11.0%，A4/4为3.9%。(2)48名日本对照的云母基因型频率如下：A9/9为6.3%，A9/6为2.1%，A9/5为2.3%，A9/6为2.1%，（5.1）为4.2%，A9/4为4.2%，A6/6为8.3%，A6/5（5.1）为16.7%，A6/4为12.5%，A5（5.1）/5（5.1）为31.3%，A5（5.1）/4为10.4%，A4/4为4.2%。(3)A9（与白塞氏病呈负相关）在印尼人中所占比例高于日本人，A6（与白塞氏病呈正相关）在印尼人中所占比例低于日本人。

1. The results of the survey of Familial Behget's disease (BD) were as follows :(1) We obtained reports on 83BD patients (41men ; 42women)with familial occurrence.(2) The positive rate of HLA-B51 was 53.1% (58.8%men ; 46.7%women)(3) The ocular lesions had a high positive correlation with HLA-B51, but had a high negative correlation with genital ulcers. The mean onset year of the patients with ocular symptoms (1973.3 ± 10.15) was lower than that of the patients without ocular symptoms(1981.3±8.78).(4) The proportion of the complete type and the patients with ocular symptoms among the patients with onset year of 1980 or later were significantly less than those among the patients with onset year of 1979 or before.2. The results of the genotyping of MICA gene by micro-satellite method in Indonesian.(1) The frequency of MICA genotypes of the 127 subjects was as follows : A9/9 was 14.1%, A9/6 was 5.5%, A9/5(5.1) was 28:3%, A9/4 was 11.0%, A6/6 was 1.5%, A6/5(5.1) was 1.5%, A6/4 was 0.79%, A5(5.1)/5(5.1) was 22.0%, A5(5.1)/4 was 11.0%, and A4/4 was 3.9%.(2) The frequency of MICA genotypes of the 48 Japanese control was as follows : A9/9 was 6.3%, A9/6 was 2.1%, A9/5(5.1) was 4.2%, A9/4 was 4.2%, A6/6 was 8.3%, A6/5(5.1) was 16.7%, A6/4 was 12.5%, A5(5.1)/5(5.1) was 31.3%, A5(5.1)/4 was 10.4%, and A4/4 was 4.2%.(3) The proportion of A9 (negative correlation with Behcet's disease) among Indonesian was higher than that, among Japanese and that of A6 (positive correlation with Behcet's disease), among Indonesian was lower than that among Japanese.