THE ASSOCIATION BETWEEN IMPULSIVENESS/AGGRESSIVENESS AND SEROTONIN RELATED GENE POLYMORPHISM

首先，我们开发了日本版的Barratt冲动性量表，第11版（BIS-11），因为日本没有评估冲动性/攻击性的工具。在将BIS-11翻译成日语后，我们对学生（N=34）和工人（N=416）的样本进行了信度和效度调查。为检验重测信度，通过分析检验与重测之间的方差计算类内系数。通过计算Cronbach’s alpha来检验内部一致性。为了了解因子效度，我们使用验证性因子分析检查了先前报告提出的三因素模型是否适合数据。结果表明，日本版BIS-11具有优异的重测信度和可接受的内部一致性信度。日本版本被认为具有与原版相似的因子结构。其次，我们研究了血清素转运基因启动子区域多态性的分布，使用了大约150份血液样本。与以往的研究结果一样，我们的研究结果表明，日本受试者更容易出现短型串联重复而不是长型串联重复。

Firstly, we developed the Japanese version of the Barratt Impulsiveness Scale, 11th version(BIS-11)since there has been no instrument for assessing impulsiveness/ aggressiveness in Japan. After translating the BIS-11 into Japanese, we investigated reliability and validity in student's(N=34)and worker's(N=416)samples. To test test-retest reliability, intraclass coefficients by analysis of variance between test and retest were calculated .Internal consistency was examined by calculating Cronbach's alpha. To see the factor validity, we examined whether or not three-factor model proposed by a previous report fit the data, using confirmatory factor analysis. The results showed that the Japanese version of the BIS-11 had excellent test-retest reliability and acceptable internal consistency reliability. The Japanese version was judged to have similar factor structure to the original one. Second, we examine the distribution of polymorphism in the promoter region of serotonin transporter gene, using about 150 blood samples. As found in previous studies, our results suggested that Japanese subjects were more likely to have the tandem repeat of short type than that of long type.