Molecularbiology of occupational urothelial tumors

在这项研究中，分析了劳动环境因素和宿主特异性因素之间的差异与致癌作用的分子生物学，因为有些人患癌症和其他人没有，即使在人群中暴露于许多化学致癌物。其次，在基因水平上比较职业性上皮性肿瘤与自发性上皮性肿瘤的差异.芳香胺染料工人谷胱甘肽S-转移酶（GSTM 1）基因的检测：我们检测了芳香胺解毒酶GSTM 1基因在癌症组和非癌症组之间的多态性。GSTM 1基因缺陷个体在肿瘤患者中有增多的趋势。在研究工作环境因素与GSTM 1基因的关系时，工作环境因素，如在小规模工厂工作和工作时间，在致癌作用上超过了GSTM 1基因缺陷.芳香胺染料工人p53基因突变检测：职业性上皮性肿瘤p53蛋白过表达明显高于一般人群上皮性肿瘤。职业性上皮性肿瘤p53基因突变频率高于一般人群。

In this study, the differences were analyzed between labor environment factors and host specific factors related to carcinogenesis in molecularepidemiology, because some people develop cancer and others do not, even in the population exposed to many chemical carcinogens. Secondly, the differences were examined between occupational epithelial tumors and spontaneous generation epithelial tumors at the gene level.1. Examination of the Glutathion S-transferase (GSTM1) gene in dye workers exposed to aromatic amines :We examined the polymorphism of the GSTM1 gene between the cancer group and the non-cancer group, which is one of the detoxic enzymes of the aromatic amines. The abounding tendency in GSTM1 gene-deficient individual was recognized in cancer patients. In examining the relationship between occupational environment factors and the GSTM1 gene, labor environment factors, such as employment in small-scale factories and the duration of employment surpassed GSTM1 gene deficiency in carcinogenesis.2. Examination of p53 gene mutation in dye workers exposed to aromatic amines :p53 protein in occupational epithelial tumors showed an overexpression which was significantly higher than in epithelial tumors in the general population. The frequency of p53 gene mutation in occupational epithelial tumors tended to be higher than tumors in the general population.