Evaluation of the effects of endocrine disruptors in synthetic compounds on several biological organisms.

37种内分泌干扰物的雌激素活性，包括塑料手套和食品包装的副产品，以及与壬基酚有关的化学品、药物和植物雌激素，通过体外和体内试验进行了测量。重组酵母菌试验和培养乳腺癌细胞试验两项体外试验的结果之间存在良好的相关性。对18种化学物质进行了大鼠阴道涂片试验。在这些化学物质中，有8种显示了本研究的结果与Dodds的结果（1938）之间的正相关。从这些相关性出发，探讨了塑料化合物、药物和植物雌激素在食品安全和生活环境中的评价方法。

The estrogenic activity of thirty seven endocrine disruptors including byproducts from plastic gloves and food wraps, and chemicals related to nonylphenol, medical drugs and phytoestrogens, were measured by in vitro and in vivo tests. There was a good correlation between the results obtained from two in vitro tests which included a recombinant yeast test and a cultured mammary cancer cell test. Eighteen chemicals were subjected to an in vivo rat vaginal smear test. Those of the chemicals subjected, eight showed a positive correlation between results obtained from the present study and the results from Dodds's results (1938). From these correlation, the evaluation methods of plastic compounds, medical drugs and phytoestrogens in food safety and living environment were discussed.