Quantum diffractive Nanoscale Microscopy

QUINS项目将利用一种基于半导体高谐波产生的极端波长的新型非经典光源来开发基于相关的量子显微镜。谐波发射来自于n纠缠光子的频率梳，频率从红外延伸到深紫外。我们将利用从该梳中选择的非简并光子的纠缠对。对产生的量子态的超快控制将减轻退相干。将产生用于先进量子成像协议的极端波长的受控相干态。QUINS技术将在量子成像（QI）中开辟新的路线，其独特的优势是将传感和分辨率从一个光谱范围转移到另一个光谱范围。这个概念将用近红外/可见对显微镜来说明，这将允许感知感染的细胞组织。未来，我们的量子显微镜将使生物和医学的非破坏性和非侵入性成像成为可能。量子灵敏度的优势在于，它使弱场成像成为可能，避免损坏脆弱的样品，如活细胞。我们将使用汉诺威医院的细胞进行测试。为了实现这些目标，我们的法德联盟涵盖了从超快激光，阿秒科学，强场量子理论，QI和探测器到先进光学设计的广泛专业知识。最后，几项技术突破将导致开发：1)量子光谱仪演示器允许我们证明近红外和可见光谐波光子之间的纠缠将实现；2)高对比度高分辨率量子显微镜将在活体散射介质上进行验证，作为概念验证。

The QUINS project will exploit a novel non-classical source of light at extreme wavelengths based on high harmonic generation in semiconductor to develop a correlation-based quantum microscope. The harmonic emission comes as a frequency comb of N-entangled photons with frequencies extending from the IR to the deep-UV. We will exploit entangled pairs from non-denegerated photons selected from this comb. Ultrafast control over the generated quantum states will mitigate decoherence. Controlled coherent states at extreme wavelengths for advanced quantum imaging protocols will be produced. QUINS technology will develop new routes in quantum imaging (QI) with a unique advantage of transferring the sensing and resolution benefit from one spectral range to another one. This concept will be illustrated with NIR/VIS pair microscopy that will allow sensing infected cells tissue. In the future, our quantum microscope will enable non-destructive and non-invasive imaging in biology and medicine. The advantage of quantum sensitivity is that it makes weak-field imaging possible, avoiding damage to delicate samples such as living cells. We will perform tests with cells from Medical Hospital Hanover. To achieve these goals, our French-German consortium covers a wide range of expertise ranging from ultrafast laser, attosecond science, strong field quantum theory, QI and detectors to advanced optical design. Finally, several technological breakthroughs will give rise to exploitation: 1) a quantum spectrometer demonstrator allowing us to certify entanglement between NIR and VIS harmonic photons will be realized 2) a high contrast high resolution quantum microscope will be validated on living scattering media as a proof of concept.