Microscopic Properties on the Structure of Biomolecules in Aqueous Solutions

为了研究生物分子在水溶液中的微观结构，本项目进行了以下结构分析：1）用中子衍射法研究铵离子的水合结构，用<14><15>中子衍射法研究尿素分子的水合结构，用中子衍射法研究<14><15>丙氨酸分子的水合结构，用中子衍射法研究<14><15>甘氨酸分子在水溶液中的水合结构<14><15>，用X射线和中子衍射技术研究了醋酸根离子的水合结构，并构造了一种新的X射线成像板保持器，使散射数据具有更高的统计精度。已完成标准样品的测量。仪器参数和数据分析程序系统的完善正在进行中。

In order to investigate microscopic structure of biomolecules in aqueous solutions, following structural analyzes have been carried out in this project;1) Hydration structure of ammonium ions studied by neutron diffraction with ^<14>N/^<15>N and H/D isotopic substitution methods.2) Hydration structure of urea molecules studied by neutron diffraction with ^<14>N/^<15>N and H/D isotopic substitution methods.3) Hydration structure of alanine molecules studied by neutron diffraction with ^<14>N/^<15>N and H/D isotopic substitution methods.4) Hydration structure of glycine molecules in aqueous acidic- and alkaline solutions studied by neutron diffraction with ^<14>N/^<15>N and H/D isotopic substitution methods.5) Hydration structure of acetate ions studied by X-ray and neutron diffraction techniques.A new X-ray imaging plate holder has been constructed, which enable to obtain scattering data with higher statistical accuracy. Measurements on standard samples have been completed. Refinements of the instrumental parameters and the program system for data analysis, are now in progress.