Does streptococcal ADP ribosyl cyclase/cADPR hydrolase evokeIgdassswitch?

1.当杂交瘤细胞与纯化的链球菌ADP核糖基环化酶/cADPR水解酶共同孵育时，没有获得明显的IG类别转换的证据.对门诊儿童链球菌性咽炎的微生物学状况进行了调查。入选临床诊断为急性咽炎的儿童。在360份检查标本中，96份（26.7%）为β-血友病链球菌（BHS）阳性。分离株的兰斯菲尔德群和T抗原均为同种型。虽然A群占优势（90株分离株，93.8%），但也检测到B群（2株分离株，2.1%）、C群（1株分离株，1.0%）和G群（3株分离株，3.1%）。值得注意的是，目前使用的抗原快速检测试验不能检测非A组链球菌。T-血清分型的结果表明，在暑假期间的人类迁移可能提供了一个机会，链球菌定植在新的主机。

1. Distinct evidence of Ig class switch was not obtained when hybridoma cells were incubated with purified streptococcal ADP ribosyl cyclase/cADPR hydrolase.2. The microbiologic status of streptococcal pharyngitis in pediatric outpatients was investigated. Children with clinical diagnosis of acute pharyngitis were enrolled. Of 360 specimens examined, 96 (26.7%) were beta hemplytic streptococci (BHS)-positive. The isolates were homogeneous for Lancefield's group and T antigen. Although group A was predominant (90 isolates, 93.8%), groups B (two isolates, 2.1%), C (one isolate, 1.0%), and G (three isolates, 3.1%) were also detected. It should be noticed that non-group A streptococci can not be detected with the currently used rapid antigen-detection tests. The results of T-serotyping suggest that human migration during summer vacation may provide an opportunity for streptococci to colonize in new hosts.